Browsing Faculty of Health Sciences (FHS) by Title
Now showing items 6161-6180 of 10378
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MRI evaluation of patients with shoulder pain at three imaging Centres in Nairobi
(2014)Background: Shoulder pain is a common reason for visiting a physician. It is the third most common cause of musculoskeletal complaint after low back pain and cervical pain in the USA. No data is available on MRI findings ... -
mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?
(University of NairobiDepartment Of Human Anatomy, 1999-04)To assess the extent to which the Nile River Valley has been a corridor for human migrations between Egypt and sub-Saharan Africa, we analyzed mtDNA variation in 224 individuals from various locations along the river. ... -
MUC1 oncoprotein is a druggable target in human prostate cancer cells.
(University of NairobiFaculty of medicine, 2009-11)Human prostate cancers are dependent on the androgen receptor for their progression. The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in prostate cancers; however, it is not known if MUC1 is of functional ... -
MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells.
(University of NairobiFaculty of medicine, 2012)BACKGROUND: The mucin 1 (MUC1) heterodimeric oncoprotein is overexpressed in human prostate cancers with aggressive pathologic and clinical features. However, few insights are available regarding the functional role of ... -
MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.
(University of NairobiFaculty of medicine, 2009)Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies. The mucin 1 (MUC1) oncoprotein is overexpressed in human carcinomas and, like NF-kappaB, blocks cell death and induces transformation. ... -
MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells.
(University of NairobiFaculty of medicine, 2012)MUC1 is a heterodimeric glycoprotein that is overexpressed in breast cancers. The present studies demonstrate that the oncogenic MUC1 C-terminal subunit (MUC1-C) associates with the TCF7L2 transcription factor. The MUC1-C ... -
MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.
(University of NairobiFaculty of medicine, 2011)Signal transducer and activator of transcription 3 (STAT3) is activated in human breast cancer and other malignancies. Mucin 1 (MUC1) is a heterodimeric cell surface glycoprotein that is overexpressed in human carcinomas ... -
MUCIN 1 Oncoprotein Expression Is Suppressed By The Mir-125b Oncomir.
(University of NairobiFaculty of medicine, 2010)The MUC1 oncoprotein is overexpressed in most human breast cancers by mechanisms that are incompletely understood. The microRNA, miR-125b, is downregulated in breast cancer cells. The present studies demonstrate that the ... -
Mucociliary Clearance Time in Patients with and without Rhinitis.
(2014)Background: Rhinitis may be allergic or non allergic. Allergic rhinitis, intermittent or persistent is the most common type of rhinitis, affecting approximately 20% of the population while nonallergic rhinitis affects ... -
Mucocutaneous manifestations of Acquired Immunodeficiency Syndrome
(University of NairobiFaculty of medicine, 1991)Abstract Not available -
Mucocutaneous manifestations of lymphomas and leukemias in black Kenyan children.
(University of NairobiSchool of medicine,University of NairobiDepartment of Pathology/Hematology, Nairobi Hospital, Kenya, 1995-04)BACKGROUND: Childhood leukemia and lymphoma are common problems in Tropical Africa, including Kenya. Studies done in Western populations indicate that 25-50% of patients with leukemia and lymphoma have specific or ... -
Mucosal and plasma IgA from HIV-1-exposed uninfected individuals inhibit HIV-1 523 transcytosis across human epithelial cells.
(Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya;, 2000)Abstract HIV-1-specific IgA has been described in the genital tract and plasma of HIV-1 highly exposed, persistently seronegative (HEPS) individuals, and IgA from these sites has been shown to neutralize HIV-1. This ... -
Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate.
(University of NairobiCollege of Health Science, 2000)Abstract OBJECTIVE: To characterize functional properties of HIV-specific IgA in samples representing both systemic and mucosal compartments of HIV-1 highly exposed persistently seronegative (HEPS) individuals. METH ... -
Mucosal blood group antigen expression profiles and HIV infections A Study among female sex workers in Kenya.
(University of Nairobi, 2015-07)Background The ABO blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be expressed on some other cells particularly the surface of epithelial cells and may ... -
Mucosal IgA in exposed, uninfected subjects: evidence for a role in protection against HIV infection
(Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya;MRC Immunology Group, Institute of Molecular Medicine, Oxford, UKDepartment of Medical Microbiology, University of Manitoba, WinnipegDepartment of Clinical Virology, Karolinska Institute, Stockholm, Sweden., 2001) -
Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses
(Department of Community Health, University of Nairobi, Nairobi, Kenya, 2008)Background: The host immune response against mucosally acquired pathogens may be influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae can impair dendritic cell and T-cell immune function, ... -
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of NairobiDepartment of Medical Microbiology, 2013-01)OBJECTIVE: Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ... -
Mucosal specimen collection, processing and assay - Experience from a resource-limited setting in Kenya
(University of Nairobi, 2013)Background: HIV-1 infection occurs most commonly through sexual intercourse. Induction of mucosal immune responses will likely be necessary for an effective HIV vaccine. KAVI embarked on building capacity for mucosal ... -
Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation.
(University of NairobiDepartment of Medical Microbiology, 2013-09)Mucosal Th17 cells maintain the gut epithelial barrier and prevent invasion by luminal bacteria through a delicate balance of immunosuppressive and proinflammatory functions. HIV infection is characterized by mucosal Th17 ... -
Mullerian agenesis: a case report
(University of Nairobi, 1988)