Browsing Faculty of Health Sciences (FHS) by Title
Now showing items 6167-6186 of 10378
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MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.
(University of NairobiFaculty of medicine, 2011)Signal transducer and activator of transcription 3 (STAT3) is activated in human breast cancer and other malignancies. Mucin 1 (MUC1) is a heterodimeric cell surface glycoprotein that is overexpressed in human carcinomas ... -
MUCIN 1 Oncoprotein Expression Is Suppressed By The Mir-125b Oncomir.
(University of NairobiFaculty of medicine, 2010)The MUC1 oncoprotein is overexpressed in most human breast cancers by mechanisms that are incompletely understood. The microRNA, miR-125b, is downregulated in breast cancer cells. The present studies demonstrate that the ... -
Mucociliary Clearance Time in Patients with and without Rhinitis.
(2014)Background: Rhinitis may be allergic or non allergic. Allergic rhinitis, intermittent or persistent is the most common type of rhinitis, affecting approximately 20% of the population while nonallergic rhinitis affects ... -
Mucocutaneous manifestations of Acquired Immunodeficiency Syndrome
(University of NairobiFaculty of medicine, 1991)Abstract Not available -
Mucocutaneous manifestations of lymphomas and leukemias in black Kenyan children.
(University of NairobiSchool of medicine,University of NairobiDepartment of Pathology/Hematology, Nairobi Hospital, Kenya, 1995-04)BACKGROUND: Childhood leukemia and lymphoma are common problems in Tropical Africa, including Kenya. Studies done in Western populations indicate that 25-50% of patients with leukemia and lymphoma have specific or ... -
Mucosal and plasma IgA from HIV-1-exposed uninfected individuals inhibit HIV-1 523 transcytosis across human epithelial cells.
(Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya;, 2000)Abstract HIV-1-specific IgA has been described in the genital tract and plasma of HIV-1 highly exposed, persistently seronegative (HEPS) individuals, and IgA from these sites has been shown to neutralize HIV-1. This ... -
Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate.
(University of NairobiCollege of Health Science, 2000)Abstract OBJECTIVE: To characterize functional properties of HIV-specific IgA in samples representing both systemic and mucosal compartments of HIV-1 highly exposed persistently seronegative (HEPS) individuals. METH ... -
Mucosal blood group antigen expression profiles and HIV infections A Study among female sex workers in Kenya.
(University of Nairobi, 2015-07)Background The ABO blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be expressed on some other cells particularly the surface of epithelial cells and may ... -
Mucosal IgA in exposed, uninfected subjects: evidence for a role in protection against HIV infection
(Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya;MRC Immunology Group, Institute of Molecular Medicine, Oxford, UKDepartment of Medical Microbiology, University of Manitoba, WinnipegDepartment of Clinical Virology, Karolinska Institute, Stockholm, Sweden., 2001) -
Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses
(Department of Community Health, University of Nairobi, Nairobi, Kenya, 2008)Background: The host immune response against mucosally acquired pathogens may be influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae can impair dendritic cell and T-cell immune function, ... -
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of NairobiDepartment of Medical Microbiology, 2013-01)OBJECTIVE: Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ... -
Mucosal specimen collection, processing and assay - Experience from a resource-limited setting in Kenya
(University of Nairobi, 2013)Background: HIV-1 infection occurs most commonly through sexual intercourse. Induction of mucosal immune responses will likely be necessary for an effective HIV vaccine. KAVI embarked on building capacity for mucosal ... -
Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation.
(University of NairobiDepartment of Medical Microbiology, 2013-09)Mucosal Th17 cells maintain the gut epithelial barrier and prevent invasion by luminal bacteria through a delicate balance of immunosuppressive and proinflammatory functions. HIV infection is characterized by mucosal Th17 ... -
Mullerian agenesis: a case report
(University of Nairobi, 1988) -
Multi-drug resistance of Escherichia coli from the urinary tract.
(University of Nairobi.Faculty of Medicine, 2003-03)OBJECTIVE: Resistance to antimicrobials of different structural classes has arisen in a multitude of bacterial species. This may complicate the therapeutic management of infections, including those of the urinary tract. ... -
Multi-locus genotyping reveals absence of genetic structure in field populations of the brown ear tick (Rhipicephalus appendiculatus) in Kenya.
(2016-02-07)Rhipicephalus appendiculatus is an important tick vector of several pathogens and parasitizes domestic and wild animals across eastern and southern Africa. However, its inherent genetic variation and population structure ... -
Multi-omics analyses reveal rumen microbes and secondary metabolites that are unique to livestock species
(University of Nairobi, 2024)Ruminant livestock, including cattle, sheep, goats, and camels, possess a distinctive digestive system with complex microbiota communities critical for feed conversion and secondary metabolite production, including greenhouse ... -
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
(University of Nairobi, 2022-05)Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used by millions of women worldwide. However, experimental studies have associated DMPA use with genital epithelial barrier disruption and ... -
A multicenter study comparing the accuracy of MRI to arthroscopy for the diagnosis of glenohumeral joint pathologies
(East African Orthopaedic Journal, 2021-04-09)Background: The number of patients with shoulder pathology who seek medical treatment is on the increase. It affects approximately18-26% of adult population. The symptoms can sometimes be debilitating affecting not only ... -
A multicenter, single-blind, prospective randomized trial to evaluate the safety of a polyethylene glycol hydrogel (Duraseal Dural Sealant System) as a dural sealant in cranial surgery.
(Department of Neurosurgery, The University of Washington and Harborview Medical Center, Seattle, WA, USA, 2012)OBJECTIVE: Incisional cerebrospinal fluid (CSF) leakage after cranial surgery is a significant cause of morbidity due to poor wound healing and infection, meningitis, and pseudomeningocele formation. Many common dural ...
