Browsing Faculty of Health Sciences (FHS) by Author "Haider, M. I."
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Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist.
Waiboci, Lillian Wangechi; Ahmed, C. M.; Mujtaba, M. G.; Flowers, L. O.; Martin, J. P.; Haider, M. I.; Johnson, H. M. (Department of Medicine. College of Health Sciences. University of Nairobi, 2007-04)Suppressor of cytokine signaling (SOCS)-1 protein modulates signaling by IFN-gamma by binding to the autophosphorylation site of JAK2 and by targeting bound JAK2 to the proteosome for degradation. We have developed a small ... -
The gamma interferon (IFN-gamma) mimetic peptide IFN-gamma (95-133) prevents encephalomyocarditis virus infection both in tissue culture and in mice
Mujtaba, M. G.; Patel, C.B.; Patel, R. A.; Flowers, L. O.; Burkhart, M. A.; Waiboci, Lillian Wangechi; Martin, J.; Haider, M. I.; Ahmed, C. M.; Johnson, H. M. (Department of Medicine. College of Health Sciences. University of Nairobi, 2006-08)We have demonstrated previously that the C-terminal gamma interferon (IFN-gamma) mimetic peptide consisting of residues 95 to 133 [IFN-gamma(95-133)], which contains the crucial IFN-gamma nuclear localization sequence ...