Browsing Faculty of Health Sciences (FHS) by Author "Hanke, T"
Now showing items 1-3 of 3
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Development of a luciferase based viral inhibition assay to evaluate vaccine induced CD8 T-cell responses.
Naarding, MA; Fernandez-Fernandez, N; Kappes, JC; Hayes, P; Ahmed, T; Icyuz, M; Edmonds, TG; Bergin, P; Anzala, O; Hanke, T; Clark, L; Cox, JH; Cormier, E; Ochsenbauer, C; Gilmour, J. (Universty of Nairobi, 2013-11)Emergence of SIV and HIV specific CD8 T cells has been shown to correlate with control of in vivo replication. Poor correlation between IFN-γ ELISPOT responses and in vivo control of the virus has triggered the development ... -
A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans.
Mwau, M; Cebere, I,; Sutton, J; Chikoti, P; Winstone, N; Wee, EG; Beattie, T; Chen, YH; Dorrell, L; McShane, H; Schmidt, C; Brooks, M; Patel, S; Roberts, J; Conlon, C; Rowland-Jones, SL; Bwayo, JJ; McMichael, AJ; Hanke, T (University of Nairobi,College of Health Sciences,, 2004-04)The immunogenicities of candidate DNA- and modified vaccinia virus Ankara (MVA)-vectored human immunodeficiency virus (HIV) vaccines were evaluated on their own and in a prime-boost regimen in phase I clinical trials in ... -
Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers
Guimarães-Walker, A; Mackie, N; McCormack, S; Hanke, T; Schmidt, C; Gilmour, J; Barin, B; McMichael, A; Weber, J; Legg, K; Babiker, A; Hayes, P; Gotch, F; Smith, C; Dally, L; Dorrell, L; Cebere, I; Kay, R; Winstone, N; Moore, S; Goonetilleke, N; Fast, P; IAVI-006 Study Group (University of NairobiSchool of medicine,University of Nairobi, 2008-12)IAVI-006 was the first large randomised, double-blinded, placebo-controlled Phase I clinical trial to systematically investigate the prime-boost strategy for induction of HIV-1 specific CD8+ cytotoxic T-lymphocytes (CTL) ...