Browsing Faculty of Health Sciences (FHS) by Author "Jager, L. D."
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The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.
Jager, L. D.; Dabelic, R.; Waiboci, Lillian Wangechi; Lau, K.; Haider, M. S.; Ahmed, C. M.; Larkin, J.; David, S.; Johnson, H. M. (2011-03)Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) ... -
SOCS-1 mimetics protect mice against lethal poxvirus infection: identification of a novel endogenous antiviral system
Ahmed, C. M.; Dabelic, R.; Waiboci, Lillian Wangechi; Jager, L. D.; Heron, L. L.; Johnson, H. M. (Department of Medicine. College of Health Sciences. University of Nairobi, 2009)The suppressor of cytokine signaling 1 (SOCS-1) protein modulates cytokine signaling by binding to and inhibiting the function of Janus kinases (JAKs), ErbB, and other tyrosine kinases. We have developed a small tyrosine ...