Browsing Faculty of Health Sciences (FHS) by Author "Lajoie, J"
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Association of sex work with reduced activation of the mucosal immune system
Lajoie, J; Kimani, M; Plummer, FA; Nyamiobo, F; Kaul, R; Kimani, J; Fowke, KR. (University of Nairobi, 2014-01)Background. Unprotected intercourse and seminal discharge are powerful activators of the mucosal immune system and are an important risk factors for HIV transmission. This study was designed to determine if female sex work ... -
A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
Lajoie, J; Juno, J; Burgener, A; Rahman, S; Mogk, K; Wachihi, C; Mwanjewe, J; Plummer, F A; Kimani, J; Ball, T B; Fowke, K R (University of Nairobi,, 2012)The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model ... -
Regulation of mucosal and systemic immune activation during the menstrual cycle of female sex workers from nairobi, kenya; local regulation and HIV-induced impairment
Boily-Larouche, G; Lajoie, J; Cheruiyot, J; Njoki, J; Kimani, M; Oyugi, J; Kimani, J; Fowke, KR (University of Nairobi, 2015)Problem: Vaginal intercourse is the main route of HIV infection among women. To result in a productive infection, HIV must encounter activated targets that sustain replication. Sexual hormones modulate activation and ...