Browsing Faculty of Health Sciences (FHS) by Author "Lakhi, S"
Now showing items 1-8 of 8
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CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.
Tang, J; Li, X; Price, MA,; Sanders, EJ; Anzala, O; Karita, E; Kamali, A; Lakhi, S; Allen, S; Hunter, E (University of Nairobi, 2015-07)In individuals with human immunodeficiency virus type 1 (HIV-1) infection, CD4:CD8 lymphocyte ratio is often recognized as a quantitative outcome that reflects the critical role of both CD4(+) and CD8(+) T-cells in HIV-1 ... -
Differences in acute retroviral syndrome by HIV-1 subtype in a multicentre cohort study in Africa.
Sanders, EJ; Price, MA; Karita, E; Kamali, A; Kilembe, W; Bekker, LG; Lakhi, S; Inambao, M; Anzala, O; Fast, PE; Gilmour, J; Powers, A (BMC, 2017-11)Symptoms of acute retroviral syndrome (ARS) may be used to identify patients with acute HIV-1 infection who seek care. ARS symptoms in African adults differ by region. We assessed whether reporting of ARS was associated ... -
Disease progression by infecting HIV-1 subtype in a seroconverter cohort in sub-Saharan Africa.
Amornkul, PN; Karita, E; Kamali, A; Rida, WN; Sanders, EJ; Lakhi, S; Price, MA; Kilembe, W; Cormier, E; Anzala, O; Latka, MH; Bekker, LG; Allen, SA; Gilmour, J; Fast, PE; The IAVI Africa HIV Prevention Partnership (Universty of Nairobi, 2013-10-09)OBJECTIVE:: To describe immunologic, virologic, and clinical HIV disease progression by HIV-1 subtype among Africans with well documented estimated dates of HIV infection (EDIs). DESIGN:: Prospective cohort. METH ... -
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
Prentice, HA; Price, MA; Porter, TR,; Cormier, E; Mugavero, MJ; Kamali, A; Karita, E; Lakhi, S; Sanders, EJ; Anzala, O; Amornkul, PN; Allen, S; Hunter, E; Kaslow, RA,; Gilmour, J; Tang, J; IAVI Africa HIV Prevention Partnership (University of Nairobi, 2014)In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ... -
HIV-1 viral control varies by viral subtype in a large cohort of African adults with incident HIV-1 infection.
Price, MA; Rida, W; Kilembe, W; Karita, E; Inambao, M; Ruzagira, E; Kamali, A; Sanders, EJ; Anzala, O; Hunter, E; Allen, S; Edward, VA; Wall, KM; Tang, JS; Fast, PE; Kaleebu, P; Lakhi, S; Mutua, G; Bekker, LG; Abu-Baker, G; Tichacek, A; Chetty, P; Latka, MH; Maenetje, P; Makkan, H; Kibengo, F; Priddy, F; Gilmour, J (Oxford Academic, 2019-04-02)Few HIV-infected persons can maintain low viral levels without therapeutic intervention. We evaluate predictors of spontaneous viral control in a prospective cohort of African adults shortly after HIV infection. Viral ... -
Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions
Li, X; Price, MA; He, D; Kamali, A; Karita, E; Lakhi, S; Sanders, EJ; Anzala, O; Amornkul, PN; Allen, S; Hunter, E; Kaslow, RA; Gilmour, J (2014)Research in the past two decades has generated unequivocal evidence that host genetic variations substantially account for the heterogeneous outcomes following human immunodeficiency virus type 1 (HIV-1) infection. In ... -
Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes
Anzala, Aggrey O.; Tang, J; Cormier, J; Price, M A; Prentice, H A; Song, W; Kamali, A; Karita, E; Lakhi, S (University of nairobiCollege of health science, 2011)As part of an ongoing study of early human immunodeficiency virus type 1 (HIV-1) infection in sub-Saharan African countries, we have identified 134 seroconverters (SCs) with distinct acute-phase (peak) and early chronic-phase ... -
Prediction of extended high viremia among newly HIV-1-infected persons in sub-Saharan Africa.
Powers, KA; Price, MA; Karita, E; Kamali, A; Kilembe, W; Allen, S; Hunter, E; Bekker, LG; Lakhi, S; Inambao, M; Anzala, O; Latka, MH; Fast, PE; Gilmour, J; Sanders, EJ (PLoS, 2018-04-03)OBJECTIVE: Prompt identification of newly HIV-infected persons, particularly those who are most at risk of extended high viremia (EHV), allows important clinical and transmission prevention benefits. We sought to determine ...