Browsing Faculty of Health Sciences (FHS) by Author "Mabuka, J"
Now showing items 1-4 of 4
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HIV-1 maternal and infant variants show similar sensitivity to broadly neutralizing antibodies, but sensitivity varies by subtype
Mabuka, J; Goo, L; Omenda, MM; Nduati, R; Overbaugh, J (University of NairobiSchool of Public Health, 2013-06-19)RATIONALE: To protect against HIV infection, passively transferred and/or vaccine-elicited neutralizing antibodies (NAbs) need to effectively target diverse subtypes that are transmitted globally. These variants are a ... -
Immune responses to measles and tetanus vaccines among Kenyan human immunodeficiency virus type 1 (HIV-1)-infected children pre- and post-highly active antiretroviral therapy and revaccination.
Farquhar, C; Wamalwa, D; Selig, S; John-Stewart, G; Mabuka, J; Majiwa, M; Sutton, W; Haigwood, N; Wariua, G; Lohman-Payne, B (University of Nairobi.Department of Paediatrics, 2009-04)BACKGROUND: : HIV-1-infected children have lower response rates after measles and tetanus immunization than uninfected children. We determined the extent to which highly active antiretroviral therapy (HAART) augments ... -
Longitudinal comparison of chemokines in breastmilk early postpartum among HIV-1-infected and uninfected Kenyan women
Bosire, R; Guthrie, BL; Lohman-Payne, B; Mabuka, J; Majiwa, M; Wariua, G; Mbori-Ngacha, DA; Richardson, B; John-Stewart, G; Farquhar, C (University of Nairobi.Center for Public Health Research, Kenya Medical Research Institute, Nairobi, KenyaDepartment of Paediatrics and Child Health, Univeristy of Nairobi, Kenya, 2007-09)Breastmilk chemokines have been associated with increased HIV-1 RNA levels in breastmilk and altered risk of mother-to-child HIV-1 transmission. To characterize CC and CXC chemokines in breastmilk postpartum, we collected ... -
Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1.
Mackelprang, RD; John-Stewart, G; Carrington, M; Richardson, B; Rowland-Jones, S; Gao, X; Mbori-Ngacha, DA; Mabuka, J; Lohman-Payne, B; Farquhar, C (University of Nairobi.Department of Paediatrics and Child Health, Univeristy of Nairobi, KenyaDepartment of Epidemiology, University of Washington, Seattle 98104, USA., 2008-04)BACKGROUND: Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune ...