Browsing Faculty of Health Sciences (FHS) by Author "MacDonald, K S"

Now showing items 1-6 of 6

    • CD8(+) Lymphocytes Respond To Different Hiv Epitopes In Seronegative And Infected Subjects. 

      Kaul, R; Dong, T; Plummer, F A; Kimani, J; Rostron, T; Kiama, P; Njagi, E; Irungu, E; Farah, B; Chakraborty, R; MacDonald, K S; Bwayo, JJ; McMichael, A; Rowland-Jones, S L (University of NairobiSchool of public Health Centre for HIV Prevention and Research, 2001-02)
      HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...

    • Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. 

      Rowland-Jones, S L; Dong, T; Fowke, K R; Kimani, J; Krausa, P; Newell, H; Blanchard, T; Ariyoshi, K; Oyugi, J; Ngugi, Elizabeth N; Bwayo, JJ; MacDonald, K S; McMichael, A J; Plummer, F A (University of NairobiDepartment of Medical Microbiology, University of Nairobi, Nairobi, 1998-11)
      Many people who remain persistently seronegative despite frequent HIV exposure have HIV-specific immune responses. The study of these may provide information about mechanisms of natural protective immunity to HIV-1. We ...

    • HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi 

      Kaul, R; Plummer, F A; Kimani, J; Dong, T; Kiama, P; Rostron, T; Njagi, E; MacDonald, K S; Bwayo, JJ; McMichael, A J; Rowland-Jones, S L (Department of Medical Microbiology, 2000)
      Understanding how individuals with a high degree of HIV exposure avoid persistent infection is paramount to HIV vaccine design. Evidence suggests that mucosal immunity, particularly virus-specific CTL, could be critically ...

    • Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. 

      Kimani, J; Oyugi, J; Njagi, Elizabeth N; Wade, J; Krausa, P; Rowland-Jones, S; Ngugi, E; Bwayo, JJ; Plummer, FA; Luscher, M A; Brunham, R C; MacDonald, K S; Fowke, K R; Dunand, V A; Nagelkerke, N J; Ball, T B; Gaur, L K (Department of Medicine, 2000-05)
      Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To ...

    • Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses 

      Shina, L Y Y; Ngugi, Elizabeth N; Kimani, J; Rebbapragada, A; Sheung, A; Kaul, R; Gray-Owen, S; Moses, S; Dobson-Belaire, W; MacDonald, K S (Department of Community Health, University of Nairobi, Nairobi, Kenya, 2008)
      Background: The host immune response against mucosally acquired pathogens may be influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae can impair dendritic cell and T-cell immune function, ...

    • Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex wo kers predating population declines in H IV prevalence 

      Kimani, J; Kaul, R; Nagclkerke, N J D; Luo, M A; MacDonald, K S; Ngugi, Elizabeth N; Fowke, K R; Ball, B T; Kariri, A; Ndinva-Achola, L; Plummer, F (Departments of Medical Microbiology, Community Health, University of Nairobi, 2008)
      OBJECTIVES: Female sex workers (FSWs) form a core group at high risk of both sexual HIV acquisition and secondary transmission. The magnitude of these risks may vary by sexual risk taking, partner HIV prevalence, host ...