Browsing Faculty of Health Sciences (FHS) by Author "Mackelprang, RD"

Now showing items 1-7 of 7

    • Distance from home to study clinic and risk of follow-up interruption in a cohort of HIV-1-discordant couples in Nairobi, Kenya. 

      Conley, NJ; Pavlinac, PB; Guthrie, BL; Mackelprang, RD; Muiru, AN; Choi, RY; Bosire, R; Gatuguta, A; Farquhar, C. (University of Nairobi, 2012)
      BACKGROUND: Longitudinal studies of HIV-1-infected individuals or those at risk of infection are subject to missed study visits that may have negative consequences on the care of participants and can jeopardize study ...

    • Incident HSV-2 Infections Are Common Among HIV-1-discordant Couples. 

      Muiru, AN; Guthrie, BL; Bosire, R; Merkel, M; Liu, AY; Choi, RY; Lohman-Payne, B; Gatuguta, A; Mackelprang, RD; Kiarie, JN; Farquhar, C (University of NairobiSchool of Medicine, 2013)
      Background. The synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) is well known, but lack of knowledge about the epidemiology of HSV-2 acquisition in HIV-1-discordant couples ...

    • Incident HSV-2 Infections Are Common Among HIV-1-discordant Couples. 

      Muiru, AN; Guthrie, BL; Bosire, R; Merkel, M; Liu, AY; Choi, RY; Lohman-Payne, B; Gatuguta, A; Mackelprang, RD; Kiarie, JN; Farquhar, C (University of NairobiFaculty of medicine, 2013-07-21)
      Background. The synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) is well known, but lack of knowledge about the epidemiology of HSV-2 acquisition in HIV-1-discordant couples ...

    • Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1. 

      Mackelprang, RD; John-Stewart, G; Carrington, M; Richardson, B; Rowland-Jones, S; Gao, X; Mbori-Ngacha, DA; Mabuka, J; Lohman-Payne, B; Farquhar, C (University of Nairobi.Department of Paediatrics and Child Health, Univeristy of Nairobi, KenyaDepartment of Epidemiology, University of Washington, Seattle 98104, USA., 2008-04)
      BACKGROUND: Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune ...

    • Predicting pregnancy in HIV-1-discordant couples. 

      Guthrie, BL; Choi, RY; Bosire, R; Kiarie, JN; Mackelprang, RD; Gatuguta, A; John-Stewart, GC; Farquhar, C (University of NairobiDepartment of Medicine, 2010-10)
      This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy ...

    • Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women. 

      Mackelprang, RD; Scoville, CW; Cohen, CR; Ondondo, RO; Bigham, AW; Celum, C; Campbell, MS; Essex, M; Wald, A; Kiarie, J; Ronald, A; Gray, G; Lingappa, JR (University of Nairobi, 2015)
      Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although ...

    • Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans. 

      Bigham, AW; Mackelprang, RD; Celum, C; De Bruyn, G; Beima-Sofie, K; John-Stewart, G; Ronald, A; Mugo, NR; Buckingham, K; Bamshad, M; Mullins, JI; McElrath, MJ (2014-01-23)
      OBJECTIVE:: We evaluated genetic variants in 51 candidate genes encoding proteins that interact with HIV-1 during the virus life cycle for association with HIV-1 outcomes in an African cohort. METHODS:: Using a ...