Browsing Faculty of Health Sciences (FHS) by Author "Maclean, I"
Now showing items 1-14 of 14
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Adult male circumcision does not reduce the risk of incident Neisseria gonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis infection: results from a randomized, controlled trial in Kenya.
Mehta, SD; Moses, S; Agot, K; Parker, C; Ndinya-Achola JO.; Maclean, I; Bailey, RC (Department of Epidemiology, University of Illinois at Chicago School of Public Health, Chicago, Illinois, USA, 2009)BACKGROUND: We examined the effect of male circumcision on the acquisition of 3 nonulcerative sexually transmitted infections (STIs). METHODS: We evaluated the incidence of STI among men aged 18-24 years enrolled in ... -
Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis.
Plummer, FA; Chubb, H; Simonsen, JN; Bosire, M; Slaney, L; Nagelkerke, NJ; Maclean, I; Ndinya-Achola, JO; Waiyaki, P; Brunham, RC (Department of Medical Microbiology, University of Manitoba, Winnipeg, CanadaDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Canada., 1994)Acute salpingitis complicating cervical gonococcal infection is a significant cause of infertility. Relatively little data are available concerning the pathophysiologic mechanisms of this disease. A cohort of 243 prostitutes ... -
Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease.
Peeling, RW; Kimani, J; Plummer, F; Maclean, I; Cheang, M; Bwayo, J; Brunham, RC (University of NairobiCollege of Health Science, 1997)Abstract To determine whether serum antibody to Chlamydia trachomatis antigens alters the risk of C. trachomatis pelvic inflammatory disease (PID), 280 female sex workers were prospectively evaluated over a 33-month ... -
Antibody to Haemophilus ducreyi among trucking company workers in Kenya.
Rakwar, J; Jackson, D; Maclean, I; Obongo, T; Bwayo, JJ; Smith, H; Mandaliya, K; Moses, S; Ndinya-Achola, JO; Kreiss, JK (University of NairobiFaculty of medicine, 1997-05)BACKGROUND AND OBJECTIVES: To determine the prevalence, correlates, and incidence of Haemophilus ducreyi antibodies, a cohort of East African trucking company employees was evaluated. STUDY DESIGN: Human immunodeficiency ... -
Antibody to Rmp (outer membrane protein 3) increases susceptibility to gonococcal infection
Plummer, FA; Chubb, H; Simonsen, JN; Bosire, M; Slaney, L; Maclean, I; Ndinya-Achola, JO; Waiyaki, P; Brunham, RC (Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada, 1993)The severe adverse effects of gonococcal infection on human fertility suggests that Neisseria gonorrhoeae would exert powerful selection for the development of a protective immune response in humans. N. gonorrhoeae is an ... -
Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009.
Mehta, SD; Maclean, I; Ndinya-Achola JO; Moses, S; Martin, I; Ronald, A; Agunda, L; Murugu, R; Bailey, RC; Melendez, J; Zenilman, JM (Division of Epidemiology and Biostatistics, University of Illinois at Chicago, ChicagoDepartment of Medical Microbiology, University of NairobiDepartments of Medical Microbiology, University of Manitoba, Winnipeg, CanadaBacteriology and Enteric Diseases Program, National Microbiology Laboratory Canadian Science Centre for Human and Animal Health, Winnipeg, CanadaUNIM Project, Kisumu, KenyaDivision of Infectious Diseases, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 2011)We evaluated antimicrobial resistance in Neisseria gonorrhoeae isolated from men enrolled in a randomized trial of male circumcision to prevent HIV. Urethral specimens from men with discharge were cultured for N. gonorrhoeae. ... -
The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group.
Brunham, RC; Kimani, J; Bwayo, J; Maitha, G; Maclean, I; Yang, C; Shen, C; Roman, S; Nagelkerke, NJ; Cheang, M; Plummer, FA (University of NairobiCollege of Health Science, 1996)Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P=.007), gonococcal infection (P=.002), human ... -
Herpes simplex virus type 2 antibody detection performance in Kisumu, Kenya, using the Herpeselect ELISA, Kalon ELISA, Western blot and inhibition testing
Smith, JS; Bailey, RC; Westreich, DJ; Maclean, I; Agot, K; Ndinya-Achola JO.; Hogrefe, W; Morrow, RA; Moses, S (University of North Carolina, Chapel Hill, North CarolinaUniversity of Illinois at Chicago, IllinoisUniversity of Manitoba, Manitoba, CanadaUniversity of Nairobi, Nairobi, Kenya, 2009)BACKGROUND: In certain parts of Africa, type-specific herpes simplex virus type 2 (HSV-2) ELISAs may have limited specificity. To date, no study has been conducted to validate HerpeSelect and Kalon type-specific HSV-2 ... -
Identification of novel risks for nonulcerative sexually transmitted infections among young men in Kisumu, Kenya
Mehta, SD; Moses, S; Ndinya-Achola JO.; Agot, K; Maclean, I; Bailey, RC (Department of Epidemiology and Biostatistics, University of Illinois, Chicago School of Public Health, IL 60622, USA, 2007)OBJECTIVES: STI prevention interventions often aim to reduce HIV incidence. Understanding STI risks may lead to more effective HIV prevention. GOAL: To identify STI risks among men aged 18-24 in Kisumu, Kenya. STUDY ... -
Increased interleukin-10 in the the endocervical secretions of women with non-ulcerative sexually transmitted diseases: a mechanism for enhanced HIV-1 transmission?
Cohen, CR; Plummer, FA; Mugo, N; Maclean, I; Shen, C; Bukusi, EA; Irungu, E; Sinei, S; Bwayo, JJ; Brunham, RC (Department of Obstetrics and Gynecology, University of Washington, Seattle 98195-6460, USA. crcohen@u.washington.edu, 1999)OBJECTIVE: Although non-ulcerative sexually transmitted diseases (STD) and bacterial vaginosis are implicated as cofactors in heterosexual HIV-1 transmission, the mechanisms have not been defined. Recent in vitro data ... -
The protective effect of male circumcision is sustained for at least 42 months: results from the Kisumu, Kenya Trial
Maclean, I; Krieger, JN; Williams, CF; Ndinya-Achola, JO (Department of Medical Microbiology, College of Health Sciences, University of Nairobi, 2008) -
A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancr
Malonza, IM; Tyndall, MW; Ndinya-Achola Jeckoniah O.; Maclean, I; Omar, S; MacDonald, KS; Perriens, J; Orle, K; Plummer, FA; Ronald, AR; Moses, S (University of NairobiFaculty of medicine, 1999-12)A randomized, double-blind, placebo-controlled clinical trial was conducted in Nairobi, Kenya, to compare single-dose ciprofloxacin with a 7-day course of erythromycin for the treatment of chancroid. In all, 208 men and ... -
Response of a sexually transmitted infection epidemic to a treatment and prevention programme in Nairobi, Kenya.
Moses, S; Ngugi, Elizabeth N; Costigan, A; Kariuki, C; Maclean, I; Brunham, RC; Plummer, FA (Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.Department of Community Health, University of Nairobi,British Columbia Centre for Disease Control, University of British Columbia, Vancouver, Canada, 2002)Although it seems possible in a developing country context such as Kenya, given appropriate inputs and a sound approach, to shift a sexually transmitted disease (STI) epidemic from phase II to III, it is not entirely clear ... -
Treatment of Chacroid with a 5-day Low Dose Erythromycin Regimen.
Anzala, AO; Plummer, FA; Melissa, M; Maclean, I; Kimani, J; Ronald, A (University of NairobiCollege of Health Science, 1992-07)