Browsing Faculty of Health Sciences (FHS) by Author "Ulmanen Ismo."
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Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.
Sludden Julieann.; Ulmanen Ismo.; Dewar Kevin.; Ismail Debbie.; Indalo Anne.; Githang'a Jessie N.; Syvänen Ann-Christine.; McLeod Howard L. (Department of Clinical Medicine and Therapeutics, 1998-06)Catechol O-methyltransferase (COMT) inactivates neurotransmitters, hormones and drugs such as levodopa. COMT activity is inherited in an autosomal recessive manner and individuals with low activity have thermolabile COMT ...