Browsing Faculty of Health Sciences (FHS) by Author "Yao, Xiao-Dan"

Now showing items 1-3 of 3

    • Anti-HIV-1 Activity of Elafin Is More Potent than Its Precursor's, Trappin-2, in Genital Epithelial Cells 

      Drannik, Anna G; Nag, Kakon; Yao, Xiao-Dan; Henrick, Bethany M; Jain, Sumiti; Ball, Blake T; Plummer, Francis A; Wachihi, Charles; Kimani, Joshua; Rosenthal, Kenneth L (Department of Medical Microbiology, 2012)
      Cervicovaginal lavage fluid (CVL) is a natural source of anti-HIV-1 factors; however, molecular characterization of the anti-HIV-1 activity of CVL remains elusive. In this study, we confirmed that CVLs from HIV-1-resistant ...

    • HIV-1 RNA Dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers 

      Lester, Richard T.; Yao, Xiao-Dan; Ball, T. Blake; McKinnon, Lyle R.; Omange, Were R.; Kaul, Rupert; Wachihi, Charles; Jaoko Walter G.; Rosenthal, Kenneth L.; Plummer, Francis A. (2009)
      Subclinical endotoxemia has been reported in HIV-1 infected persons and may drive systemic immune activation and pathogenesis. Proinflammatory responsiveness to endotoxin (LPS) is mediated by Toll-like receptor 4 (TLR4). We ...

    • Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection 

      Lester, Richard T.; Yao, Xiao-Dan; Ball, T. Blake; McKinnon, Lyle R.; Kaul, Rupert; Wachihi, Charles; Jaoko Walter G.; Plummer, Francis A.; Rosenthal, Kenneth L. (2008)
      Toll-like receptors (TLR) are important in pathogen recognition and may play a role in HIV disease. We evaluated the effect of chronic untreated and treated HIV-1 infection on systemic TLR expression and TLR signalling. ...