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Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants.
(2005)
Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been ...
Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission.
(2012)
Breast milk is a major route of infant HIV infection, yet the majority of breast-fed, HIV-exposed infants escape infection by unknown mechanisms. This study aimed to investigate the role of HIV-specific breast milk cells ...
Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition
(University of Nairobi., 2010-06)
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women ...
Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1.
(University of Nairobi., 2008-04)
BACKGROUND:
Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune ...
Predictors of mortality in HIV-1 exposed uninfected post-neonatal infants at the Kenyatta National Hospital, Nairobi.
(University of Nairobi., 2005-09)
OBJECTIVES:
To identify potential predictors of mortality, to determine mortality rate and to identify prevalent causes of death in a cohort of HIV-1 exposed uninfected infants.
DESIGN:
Prospective cohort study.
SETT ...
Prevalence and magnitude of human immunodeficiency virus (HIV) type 1-specific lymphocyte responses in breast milk from HIV-1-seropositive women.
(2003)
Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during ...
Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding.
(University of Nairobi., 2007-03)
Previous studies of HIV-1 variants transmitted from mother-to-infant have focused primarily on computational analyses of partial envelope gene sequences, rather than analyses of functional envelope variants. There are very ...
Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant
(University of Nairobi., 2006-01)
Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human ...
Breast-feeding and Transmission of HIV-1.
(University of Nairobi., 2004-02)
Breast-feeding substantially increases the risk of HIV-1 transmission from mother to child, and although peripartum antiretroviral therapy prophylaxis significantly decreases the risk of mother-to-child transmission around ...
Performance of Clinical Algorithms for HIV-1 Diagnosis and Antiretroviral Initiation among HIV-1-Exposed Children Aged Less Than 18 Months in Kenya
(2009-04)
Background
Ninety percent of HIV-1-infected children live in sub-Saharan Africa. In the absence of diagnosis and antiretroviral therapy (ART), approximately 50% die before 2 years.
Methods
We evaluated sensitivity ...