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Comparison of techniques for HIV-1 RNA detection and quantitation in cervicovaginal secretions.
(University of Nairobi., 2001-02)
PRINCIPLES:
HIV-1 in female genital secretions has been measured using swabs, Sno Strips (Akorn, Inc., Buffalo Grove, IL), and cervicovaginal lavage (CVL), but little is known regarding the comparability of these collection ...
Modified vaccinia Ankara expressing HIVA antigen stimulates HIV-1-specific CD8 T cells in ELISpot assays of HIV-1 exposed infants[star]
(2005)
Recombinant modified vaccinia virus Ankara expressing HIV-1 antigens (MVA.HIVA) was used in ELISpot assays to monitor HIV-1-specific T cell responses in infants. Responses to MVA.HIVA and HIV-1 peptides were examined in ...
Morbidity among HIV-1–infected mothers in Kenya prevalence and correlates of illness during 2-year postpartum follow-up
(2007)
Background: Much of the burden of morbidity affecting women of
childbearing age in sub-Saharan Africa occurs in the context of HIV-1
infection. Understanding patterns of illness and determinants of
disease in HIV-1–infected ...
Low risk of death, but substantial program attrition, in pediatric HIV treatment cohorts in Sub-Saharan Africa
(University of Nairobi., 2008-12)
BACKGROUND:
To date, an estimated 10% of children eligible for antiretroviral treatment (ART) receive it, and the frequency of retention in programs is unknown. We evaluated the 2-year risks of death and loss to follow-up ...
Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children.
(University of Nairobi, 2007)
To describe the early response to World Health Organization (WHO)-recommended nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line highly active antiretroviral therapy (HAART) in HIV-1-infected Kenyan ...
Shadow on the continent: public health and HIV/AIDS in Africa in the 21st century.
(University of Nairobi., 2002-07)
Approaches to the prevention and control of the HIV/AIDS epidemic in Africa have been heavily based on early experiences and policies from industrialised countries, where the disease affects specific risk groups. HIV/AIDS ...
Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1.
(University of Nairobi., 2008-04)
BACKGROUND:
Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune ...
Predictors of mortality in HIV-1 exposed uninfected post-neonatal infants at the Kenyatta National Hospital, Nairobi.
(University of Nairobi., 2005-09)
OBJECTIVES:
To identify potential predictors of mortality, to determine mortality rate and to identify prevalent causes of death in a cohort of HIV-1 exposed uninfected infants.
DESIGN:
Prospective cohort study.
SETT ...
Timing of breast milk HIV-1 transmission: a meta-analysis
(2001-02)
:
To define the frequency and timing of breast milk transmission of HIV-1.
DESIGN:
Meta-analysis of data abstracted from published literature.
SUBJECTS:
Participants in prospective cohort studies of MTCT ...
Prevalence and magnitude of human immunodeficiency virus (HIV) type 1-specific lymphocyte responses in breast milk from HIV-1-seropositive women.
(2003)
Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during ...