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Alternative pre-approved and novel therapies for the treatment of anthrax.
(University of Nairobi, 2016)
BACKGROUND:
Bacillus anthracis, the causative agent of anthrax, is a spore forming and toxin producing rod-shaped bacterium that is classified as a category A bioterror agent. This pathogenic microbe can be transmitted ...
Development of basic obstetric theater facility in a low-resource setting.
(University of Nairobi, 2016)
In any given population or community, 15% of pregnant women can be expected to develop complications during pregnancy or delivery, and will require emergency obstetric care. Emergency preparedness should include establishing ...
Distinct genital tract hiv-specific antibody profiles associated with tenofovir gel
(University of Nairobi, 2016)
The impact of topical antiretrovirals for pre-exposure prophylaxis on humoral responses following HIV infection is unknown. Using a binding antibody multiplex assay, we investigated HIV-specific IgG and IgA responses to ...
Hepatitis B infection is highly prevalent among patients presenting with jaundice in Kenya
(University of Nairobi, 2016)
Background
Viral hepatitis is a major concern worldwide, with hepatitis A (HAV) and E (HEV) viruses showing sporadic outbreaks while hepatitis B (HBV) and C (HCV) viruses are associated with chronic hepatitis, cirrhosis ...
Factors associated with preference for early infant male circumcision among a representative sample of parents in Homa bay county, western Kenya.
(University of Nairobi, 2016)
Several countries scaling-up adult medical male circumcision (MMC) for HIV prevention intend to introduce early infant male circumcision (EIMC). To assess preference for EIMC in a community with a mature adult MMC program, ...
Acceptance of treatment of sexually transmitted infections for stable sexual partners by female sex workers in Kampala, Uganda
(University of Nairobi, 2016)
Background
The prevalence of sexually transmitted infections (STIs) among female sex workers (FSWs) in sub-Saharan Africa remains high. Providing treatment to the affected FSWs is a challenge, and more so to their stable ...
Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays.
(University of Nairobi, 2016)
One common feature of most neurodegenerative diseases, including Alzheimer's disease (AD) and stroke, is the death of neuronal cells. Neuronal cell death is associated with apoptosis, generation of reactive oxygen species ...
Participatory approaches involving community and healthcare providers in family planning/contraceptive information and service provision: a scoping review
(University of Nairobi, 2016)
As efforts to address unmet need for family planning and contraception (FP/C) accelerate, voluntary use, informed choice and quality must remain at the fore. Active involvement of affected populations has been recognized ...
Better outcomes through learning, data, engagement, and research (bolder) – a system for improving evidence and clinical practice in low and middle income countries
(University of Nairobi, 2016)
Despite the many thousands of research studies published every year, evidence for making clinical decisions is often lacking. The main problem is that the evidence available is generated in conditions very different from ...
Building capacity in implementation science research training at the University of Nairobi
(University of Nairobi, 2016)
Background
Health care systems in sub-Saharan Africa, and globally, grapple with the problem of closing the gap between evidence-based health interventions and actual practice in health service settings. It is essential ...