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Lack of Fetuin-A (α2-HS-Glycoprotein) Reduces Mammary Tumor Incidence and Prolongs Tumor Latency via the Transforming Growth Factor-β Signaling Pathway in a Mouse Model of Breast Cancer
(2010-11)
The present analyses were done to define the role of fetuin-A (Fet) in mammary tumorigenesis using the polyoma middle T antigen (PyMT) transgenic mouse model. We crossed Fet-null mice in the C57BL/6 background with PyMT ...
Xeroderma pigmentosum: a review and case series
(University of Nairobi, 2010-10)
Xeroderma pigmentosa (XP) is a condition inherited as an autosomal recessive trait and is characterized by photosensitivity, pigmentary changes, premature skin ageing and malignant tumour development resulting from the ...
Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon.
(University of Nairobi,, 2010)
Malaria is still one of the major public health threats in sub-Saharan Africa. An effective vaccine could be a sustainable control measure that can be integrated into existing health infrastructures. The malaria vaccine ...
Is vaccine the magic bullet for malaria elimination? A reality check.
(University of Nairobi,, 2010-12)
Malaria remains a major health burden especially for the developing countries. Despite concerted efforts at using the current control tools, such as bed nets, anti malarial drugs and vector control measures, the disease ...
Smokers and non - smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST - RA database
(University of Nairobi, 2010)
OBJECTIVES:
To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status.
METHODS:
The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen ...
Tropical parasitic diseases
(2010)
The term “parasitic diseases” is used in a restricted sense to refer to those diseases caused by protozoa
(malaria, schistosomiasis, leishmaniasis, trypanosomiasis, amoebiasis, giardiasis) and helminths
(hookworm, ascaris, ...
Total hip replacements at Kikuyu Hospital, Kenya
(2010)
Background: Total joint arthroplasty is a highly effective procedure that is frequently performed in elderly patients. This is not so in the third world and is not frequently performed. Total hip replacement (THR) relieves ...
Factors determining community participation in afforestation projects in River Nyando basin, Kenya
(2010)
Factors determining community participation in afforestation projects were investigated. Data was collected from 150 respondents who were selected from a sample population of 1,928 households using systematic random sampling ...
Resistance to antibiotics in urinopathogenic bacteria isolated in patients attending Kenyatta University Health Clinic, Nairobi.
(KMA, 2010)
OBJECTIVE:
To determine the aetiological bacterial agents of urinary tract infections, within communities in Kenyatta University, and current resistance levels to commonly available therapeutic agents.
DESIGN:
Cross-sectional ...
Reduced HIV-1 long terminal repeat transcription in subjects with protective interferon regulatory factor-1 genotype: A potential mechanism mediating resistance to infection by HIV-1
(2010)
We previously described the polymorphism in the interferon regulatory factor-1 (IRF-1) gene as a novel correlate of resistance to HIV-1 infection in a Kenyan female sex worker cohort. However, the underlying mechanisms ...