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Effect of acquisition and treatment of cervical infections on HIV-1 shedding in women on antiretroviral therapy
(2010)
BACKGROUND:
Cervicitis increases the quantity of HIV-1 RNA in cervical secretions when women are not taking antiretroviral therapy (ART), and successful treatment of cervicitis reduces HIV-1 shedding in this ...
Influence of exposure history o the immunology and development of resistance to human Schistosomiasis mansoni
(University of Nairobi, 2010-03)
BACKGROUND:
Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms.
METHODOLOGY/PRINCIPAL ...
The Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI): I. Construct validity
(2010)
The Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI) is a measure adapted from the National Institutes of Health Stroke Scale (NIHSS), and is intended to capture essential neurological deficits impacting ...
Increases in levels of schistosome-specific immunoglobulin E and CD23 (+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with schistosoma mansoni.
(University of Nairobi, 2010-08)
BACKGROUND:
Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence. We conducted a 2-year longitudinal study to ...
Evaluation of POSSUM and P-POSSUM as predictors of mortality and morbidity in patients undergoing laparotomy at a referral hospital in Nairobi, Kenya
(2010)
The Physiological and Operative Severity Score for enumeration of
Morbidity and Mortality (POSSUM) and its Portsmouth modification
(P-POSSUM) were developed for comparative audit in surgical patients.
This study evaluated ...
Patterns of Injuries After Road Traffic Crashes involving Bodabodas
(2010)
Background
Trauma is a leading cause of morbidity and mortality in Africa. Bodabodas
are a main form of transport in Kampala and are becoming a major cause road traffic crashes.
Majority of the patients were young males ...
A Trim5alpha Exon 2 Polymorphism is Associated with Protection from HIV-1 Infection in Pumwani Sexworker Cohort
(2010)
Objective
The innate immune component TRIM5α has the ability to restrict retrovirus infection in a species-specific manner. TRIM5α of some primate species restricts infection by HIV-1, while huTRIM5α lacks this specificity. ...
Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial.
(University of Nairobi, 2010)
BACKGROUND:
Visceral leishmaniasis (VL) is a major health problem in developing countries. The untreated disease is fatal, available treatment is expensive and often toxic, and drug resistance is increasing. Improved ...
Schistosomes of small mammals from the Lake Victoria Basin, Kenya: new species, familiar species, and implications for schistosomiasis control.
(University of Nairobi, 2010)
Recent schistosomiasis control efforts in sub-Saharan Africa have focused nearly exclusively on treatment of humans with praziquantel. However, the extent to which wild mammals act as reservoirs for Schistosoma mansoni and ...
Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi.
(University of Nairobi, 2010-08)
BACKGROUND:
We assessed whether 7 days of zidovudine + lamivudine postpartum with single-dose nevirapine at labor decreases nevirapine resistance in HIV-infected women in Malawi.
METHODS:
HIV-infected pregnant women ...