Search
Now showing items 1-10 of 14
Investigating The Utility Of The Hiv-1 Bed Capture Enzyme Immunoassay Using Cross-sectional And Longitudinal Seroconverter Specimens From Africa.
(University of Nairobi, 2007)
BACKGROUND:
The identification of populations at risk of HIV infection is a priority for trials of preventive technologies, including HIV vaccines. To quantify incidence traditionally requires laborious and expensive ...
Developing standards of care for HIV prevention research in developing countries – a case study of ten research centers in Eastern and Southern Africa
(2012-09)
Background:
Standards of care in general vary across countries and communities and thus may affect decisions about standards of care provided by research centers in HIV prevention research. To serve as a basis for ...
Sensitivity and specificity of HIV rapid tests used for research and voluntary counselling and testing
(2008-10)
Background: HIV rapid tests (RT) are a quick and non-technically demanding means
to perform HIV voluntary counselling and testing (VCT) but understanding their
limitations is vital to delivering quality VCT.
Objective: ...
CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.
(University of Nairobi, 2015-07)
In individuals with human immunodeficiency virus type 1 (HIV-1) infection, CD4:CD8 lymphocyte ratio is often recognized as a quantitative outcome that reflects the critical role of both CD4(+) and CD8(+) T-cells in HIV-1 ...
Disease progression by infecting HIV-1 subtype in a seroconverter cohort in sub-Saharan Africa.
(Universty of Nairobi, 2013-10-09)
OBJECTIVE::
To describe immunologic, virologic, and clinical HIV disease progression by HIV-1 subtype among Africans with well documented estimated dates of HIV infection (EDIs).
DESIGN::
Prospective cohort.
METH ...
Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions
(2014)
Research in the past two decades has generated unequivocal evidence that host genetic variations substantially account for the heterogeneous outcomes following human immunodeficiency virus type 1 (HIV-1) infection. In ...
HIV-1 viral control varies by viral subtype in a large cohort of African adults with incident HIV-1 infection.
(Oxford Academic, 2019-04-02)
Few HIV-infected persons can maintain low viral levels without therapeutic intervention. We evaluate predictors of spontaneous viral control in a prospective cohort of African adults shortly after HIV infection. Viral ...
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
(University of Nairobi, 2014)
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ...
Pregnancy and HIV Disease progression in an early infection cohort from five African countries.
(Unuversity of Nairobi, 2017)
BACKGROUND:
Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women.
METHODS:
From 2006 to 2011, women less than age 40 ...