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Investigating The Utility Of The Hiv-1 Bed Capture Enzyme Immunoassay Using Cross-sectional And Longitudinal Seroconverter Specimens From Africa.
(University of Nairobi, 2007)
BACKGROUND:
The identification of populations at risk of HIV infection is a priority for trials of preventive technologies, including HIV vaccines. To quantify incidence traditionally requires laborious and expensive ...
Developing standards of care for HIV prevention research in developing countries – a case study of ten research centers in Eastern and Southern Africa
(2012-09)
Background:
Standards of care in general vary across countries and communities and thus may affect decisions about standards of care provided by research centers in HIV prevention research. To serve as a basis for ...
Sensitivity and specificity of HIV rapid tests used for research and voluntary counselling and testing
(2008-10)
Background: HIV rapid tests (RT) are a quick and non-technically demanding means
to perform HIV voluntary counselling and testing (VCT) but understanding their
limitations is vital to delivering quality VCT.
Objective: ...
Health-care Providers'perceptions Of Intravaginal Rings For Hiv Prevention In Nairobi, Kenya
(2013)
Background: Health-care providers form the backbone of health information and service delivery in many African communities. This study investigated health-care providers' (HCPs) attitudes towards a novel method of HIV ...
Identifying at-risk populations in Kenya and South Africa: HIV incidence in cohorts of men who report sex with men, sex workers, and youth.
(2012)
To identify and describe populations at risk for HIV in 3 clinical research centers in Kenya and South Africa.
DESIGN:
Prospective cohort study.
METHODS:
Volunteers reporting recent sexual activity, multiple partners, ...
Total lymphocyte count as a surrogate marker for CD4+ t cell count in initiating antiretroviral therapy at Kenyatta National Hospital, Nairobi.
(2007)
To evaluate the utility of Total Lymphocyte Count (TLC) as a surrogate marker for CD4 + T cell count in antiretroviral (ARV) treatment initiation in a Kenyan population of HIV seropositive patients at Kenyatta National ...
CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.
(University of Nairobi, 2015-07)
In individuals with human immunodeficiency virus type 1 (HIV-1) infection, CD4:CD8 lymphocyte ratio is often recognized as a quantitative outcome that reflects the critical role of both CD4(+) and CD8(+) T-cells in HIV-1 ...
Disease progression by infecting HIV-1 subtype in a seroconverter cohort in sub-Saharan Africa.
(Universty of Nairobi, 2013-10-09)
OBJECTIVE::
To describe immunologic, virologic, and clinical HIV disease progression by HIV-1 subtype among Africans with well documented estimated dates of HIV infection (EDIs).
DESIGN::
Prospective cohort.
METH ...
Phase I Safety and Immunogenicity of Electroporated HIV DNA with or Without Interleukin 12 in Healthy HIVSeronegative African Volunteers
(University of Nairobi, 2013)
Background: DNA vaccines have typically been safe in clinical
trials, but weakly immunogenic. Strategies to enhance their immunogenicity
include i) co-administration of adjuvants and ii)
intramuscular administration by ...
αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission
(University of Nairobi, 2018)
Cell surface expression of α4β7, α4β1 and αEβ7 integrins play a key role in T cell distribution. Understanding the contribution of integrins to the density and ratios of CD4+: CD4negT cell at the portals of entry for HIV ...