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Herpes Simplex Virus Type 2, Genital Ulcers and HIV-1 Disease Progression in Postpartum Women
(2011)
Background
Co-infection with herpes simplex virus type 2 (HSV-2) has been associated with increased HIV-1 RNA levels and immune activation, two predictors of HIV-1 progression. The impact of HSV-2 on clinical outcomes ...
Maternal Human Leukocyte Antigen - A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission
(2010)
We examined associations between maternal HLA and vertical HIV-1 transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified using sequence-specific oligonucleotide probes and ...
Infant Safety during and after Maternal Valacyclovir Therapy in Conjunction with Antiretroviral HIV-1 Prophylaxis in a Randomized Clinical Trial
(2012)
Background
Maternal administration of the acyclovir prodrug valacyclovir is compatible with pregnancy and breastfeeding. However, the safety profile of prolonged infant and maternal exposure to acyclovir in the context ...
Establishing and sustaining a healthy vaginal environment:
(2011)
Data from a randomized trial of oral periodic presumptive
treatment (PPT) to reduce vaginal infections were analyzed
to assess the effect of the intervention on a healthy vaginal
environment (normal flora confirmed by ...
Latent TB detection by interferon gamma release assay (IGRA) in pregnancy predicts active TB and mortality in HIV-1 infected women and their children
(2010)
Background—We evaluated the prognostic utility of interferon-gamma release assays (IGRAs)
for active tuberculosis (TB) and mortality in Kenyan HIV-1 infected women and their infants.
Methods—Prevalence and correlates of ...
Effects of Valcyclovir on markers of disease Progression in Postpartum Women Co-Infected with HIV-1 andHerpes Simplex Virus-2
(2012-06)
Objective:
Herpes simplex virus type 2 (HSV-2) suppression has been shown to reduce HIV-1 disease progression in nonpregnant
women and men, but effects on pregnant and postpartum women have not been described.
Methods:
We ...
Male Antenatal Attendance and HIV Testing Are Associated with Decreased Infant HIV Infection and Increased HIV Free Survival
(2012)
Objective
To investigate the relationship between male involvement in prevention of mother-to-child HIV transmission (PMTCT) services and infant HIV acquisition and mortality a prospective cohort study was undertaken ...
Home-based HIV testing for men preferred over clinic-based testing by pregnant women and their male partners, a nested cross-sectional study
(University of Nairobi, 2015)
Background
Male partner HIV testing and counseling (HTC) is associated with enhanced uptake of prevention of mother-to-child HIV transmission (PMTCT), yet male HTC during pregnancy remains low. Identifying settings ...
Sustained responses to measles revaccination in HIV Infected Children on ART in Kenya
(University of Nairobi, 2015-02-26)
Background: Despite recent advances in reducing measles incidence in Africa, a number of measles outbreaks have occurred in countries with high HIV prevalence. One
hypothesis is that there is a growing population of ...
The role of G protein gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
(2012)
Background
The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to antiretroviral ...