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Acting Locally: Innate Mucosal Immunity In Resistance To Hiv-1 Infection In Kenyan Commercial Sex Workers.
(University of Nairobi, 2013-06)
Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ...
HLA-G And Mother-child Perinatal HIVTransmission
(University of Nairobi, 2013-04)
Transplacental passage is a well-known phenomenon in HIV infection and immune responses at the maternal-fetal interface play a critical role in perinatal mother-to-child HIV transmission (MCHT). The high expression of HLA-G ...
Associations Of Human Leukocyte Antigen-g With Resistance And Susceptibility To Hiv-1 Infection In The Pumwani Sex Worker Cohort.
(University of Nairobi, 2013-01)
OBJECTIVE:
To determine the association between human leukocyte antigens (HLA)-G genotypes and resistance or susceptibility to HIV-1.
DESIGN:
A group of sex workers in Pumwani, Kenya can be epidemiologically defined ...
Enrichment Of Variations In KIR3DL1/S1 And KIR2DL2/L3 Among H1n1/09 Icu Patients: An Exploratory Study
(University of Nairobi, 2011)
BACKGROUND:
Infection by the pandemic influenza A (H1N1/09) virus resulted in significant pathology among specific ethnic groups worldwide. Natural Killer (NK) cells are important in early innate immune responses to ...
Altered Dendritic Cell-natural Killer Interaction In Kenyan Sex Workers Resistant To Hiv-1 Infection.
(University of Nairobi, 2012-02)
BACKGROUND:
Natural killer (NK) cells are members of the innate immune system that play an important role in the defense against viral infection. They are also involved in the regulation of adaptive immune responses ...
The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans
(University of Nairobi, 2011)
Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, ...
Reducing HIV Transmission in Developing Countries
(2011-04-13)
Although the global response to the HIV/AIDS epidemic in the developing world has, in general, been inadequate, there are key interventions which have been proven to be effective in reducing the incidence of HIV and relevant ...
Hiv-specific T Cells: Strategies For Fighting A Moving Target.
(University of Nairobi, 2010)
HIV vaccine development faces many hurdles, including the failure of empirical approaches, an incomplete understanding of protective immunity, and the extreme genetic diversity of HIV-1. HIV is a moving target in at least ...
Epigenetic Control Of Irf1 Responses In HIV-exposed Seronegative Versus HIV-susceptible Individuals.
(University of Nairobi, 2011-03)
Not all individuals exposed to HIV become infected. Understanding why these HIV-exposed seronegative individuals remain uninfected will help inform the development of preventative measures against HIV infection. Interferon ...
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.
(2010)
BACKGROUND:
Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ...