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Developing standards of care for HIV prevention research in developing countries – a case study of ten research centers in Eastern and Southern Africa
(2012-09)
Background:
Standards of care in general vary across countries and communities and thus may affect decisions about standards of care provided by research centers in HIV prevention research. To serve as a basis for ...
CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.
(University of Nairobi, 2015-07)
In individuals with human immunodeficiency virus type 1 (HIV-1) infection, CD4:CD8 lymphocyte ratio is often recognized as a quantitative outcome that reflects the critical role of both CD4(+) and CD8(+) T-cells in HIV-1 ...
Disease progression by infecting HIV-1 subtype in a seroconverter cohort in sub-Saharan Africa.
(Universty of Nairobi, 2013-10-09)
OBJECTIVE::
To describe immunologic, virologic, and clinical HIV disease progression by HIV-1 subtype among Africans with well documented estimated dates of HIV infection (EDIs).
DESIGN::
Prospective cohort.
METH ...
Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions
(2014)
Research in the past two decades has generated unequivocal evidence that host genetic variations substantially account for the heterogeneous outcomes following human immunodeficiency virus type 1 (HIV-1) infection. In ...
HIV-1 viral control varies by viral subtype in a large cohort of African adults with incident HIV-1 infection.
(Oxford Academic, 2019-04-02)
Few HIV-infected persons can maintain low viral levels without therapeutic intervention. We evaluate predictors of spontaneous viral control in a prospective cohort of African adults shortly after HIV infection. Viral ...
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
(University of Nairobi, 2014)
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ...
Pregnancy and HIV Disease progression in an early infection cohort from five African countries.
(Unuversity of Nairobi, 2017)
BACKGROUND:
Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women.
METHODS:
From 2006 to 2011, women less than age 40 ...
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
(2016)
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the ...
Differences in acute retroviral syndrome by HIV-1 subtype in a multicentre cohort study in Africa.
(BMC, 2017-11)
Symptoms of acute retroviral syndrome (ARS) may be used to identify patients with acute HIV-1 infection who seek care. ARS symptoms in African adults differ by region. We assessed whether reporting of ARS was associated ...
Prediction of extended high viremia among newly HIV-1-infected persons in sub-Saharan Africa.
(PLoS, 2018-04-03)
OBJECTIVE:
Prompt identification of newly HIV-infected persons, particularly those who are most at risk of extended high viremia (EHV), allows important clinical and transmission prevention benefits. We sought to determine ...