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Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions
(2014)
Research in the past two decades has generated unequivocal evidence that host genetic variations substantially account for the heterogeneous outcomes following human immunodeficiency virus type 1 (HIV-1) infection. In ...
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
(University of Nairobi, 2014)
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ...
Clinical safety and immunogenicity of two hiv vaccines sev-g (np) and ad35-grin in HIV-uninfected, healthy adult volunteers
(University of Nairobi, 2014)
Development of vaccines that stimulate sustained humoral and/or cellular
immunity at mucosal HIV entry points is critical in the quest for an HIV vaccine. To achieve
this goal, we are investigating replication-competent ...