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Now showing items 1-9 of 9
Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial.
(2014)
Abstract
BACKGROUND:
Antiretroviral pre-exposure prophylaxis (PrEP), with daily oral tenofovir disoproxil fumarate or tenofovir disoproxil fumarate in combination with emtricitabine, has been shown to be efficacious ...
A prospective study of contraceptive use among African women in HIV-1 serodiscordant partnerships.
(Univesity of Nairobi, 2010-10)
BACKGROUND:
Dual contraception is important for averting HIV-1 transmission, unintended pregnancy, and maternal-to-child HIV-1 transmission. Few studies have explored contraceptive use in HIV-1 serodiscordant couples, ...
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
(2010)
Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital ...
A prospective study of the effect of pregnancy on CD4 counts and plasma HIV-1 RNA concentrations of antiretroviral-naive HIV-1-infected women.
(University of Nairobi, 2014-02)
BACKGROUND:
In HIV-1-infected women, CD4 count declines occur during pregnancy, which has been attributed to hemodilution. However, for women who have not initiated antiretroviral therapy, it is unclear if CD4 declines ...
Pre-exposure prophylaxis for HIV-1 prevention does not diminish the pregnancy prevention effectiveness of hormonal contraception.
(University of Nairobi, 2014)
BACKGROUND:
For women at risk of HIV-1, effective contraception and effective HIV-1 prevention are global priorities.
METHODOLOGY:
In a clinical trial of pre-exposure prophylaxis (PrEP) for HIV-1 prevention in ...
Reversibility of glomerular renal function decline in hiv-uninfected men and women discontinuing emtricitabine-tenofovir disoproxil fumarate pre-exposure prophylaxis.
(University of Nairobi, 2016)
BACKGROUND:
Tenofovir disoproxil fumarate (TDF) pre-exposure prophylaxis (PrEP) use is associated with a small but statistically significant decline in estimated glomerular filtration rate (eGFR). We investigated the ...
Low risk of proximal tubular dysfunction associated with emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis in men and women.
(University of Nairobi, 2016)
OBJECTIVE:
Tenofovir disoproxil fumarate (TDF) is associated with proximal tubular dysfunction (tubulopathy) when used in the treatment of human immunodeficiency virus (HIV) infection. We evaluated whether TDF causes ...
Changes in Glomerular Kidney Function Among HIV-1-Uninfected Men and Women Receiving Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis: A Randomized Clinical Trial.
(University of Nairobi, 2014)
Importance:
Tenofovir disoproxil fumarate (TDF) use has been associated with declines in the estimated glomerular filtration rate (eGFR) when used as part of antiretroviral treatment by persons with human immunodeficiency ...
A scoring tool to identify East African HIV-1 serodiscordant partnerships with a high likelihood of pregnancy.
(University of Nairobi, 2015)
INTRODUCTION:
HIV-1 prevention programs targeting HIV-1 serodiscordant couples need to identify couples that are likely to become pregnant to facilitate discussions about methods to minimize HIV-1 risk during pregnancy ...