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Now showing items 1-7 of 7
Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial.
(Univesity of Nairobi, 2011-03)
BACKGROUND:
Characterization of viruses in HIV-1 transmission pairs will help identify biological determinants of infectiousness and evaluate candidate interventions to reduce transmission. Although HIV-1 sequencing is ...
Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission.
(Univesity of Nairobi, 2011-04)
High plasma HIV-1 RNA concentrations are associated with an increased risk of HIV-1 transmission. Although plasma and genital HIV-1 RNA concentrations are correlated, no study has evaluated the relationship between genital ...
Increased risk of HIV-1 transmission in pregnancy: a prospective study among African HIV-1-serodiscordant couples.
(Univesity of Nairobi, 2011-09)
Physiologic and behavioral changes during pregnancy may alter HIV-1 susceptibility and infectiousness. Prospective studies exploring pregnancy and HIV-1 acquisition risk in women have found inconsistent results. No study ...
Increased risk of HIV-1 transmission in pregnancy: a prospective study among African HIV-1-serodiscordant couples.
(2011)
Physiologic and behavioral changes during pregnancy may alter HIV-1 susceptibility and infectiousness. Prospective studies exploring pregnancy and HIV-1 acquisition risk in women have found inconsistent results. No study ...
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
(2010)
Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital ...
Herpes simplex virus type 2 suppressive therapy with acyclovir or valacyclovir does not select for specific HIV-1 resistance in HIV-1/HSV-2 dually infected persons.
(Univesity of Nairobi, 2011-01)
Recent in vitro studies suggest that acyclovir may directly inhibit HIV-1 replication and can select for a specific HIV-1 reverse transcriptase mutation (V75I) with concomitant loss of an anti-HIV-1 effect. We tested for ...
Daily Acyclovir to Decrease Herpes Simplex Virus Type 2 (HSV-2) Transmission from HSV-2/HIV-1 Coinfected Persons: A Randomized Controlled Trial.
(University of Nairobi, 2013)
Background. Daily suppressive therapy with valacyclovir reduces risk of sexual transmission of herpes simplex virus type 2 (HSV-2) in HSV-2-serodiscordant heterosexual couples by 48%. Whether suppressive therapy reduces ...