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Common antimalarial drugs do not affect the metabolism of diazepam and desmethyldiazepam by human liver microsomes
(University of Nairobi., 1996)
Steady-state anticonvulsant drug levels in epileptic patients
(1996)
Steady state concentrations of three anticonvulsant drugs (phenobarbitone, phenytoin and carbamazepine) were measured in plasma samples from fifteen patients (eight males and seven females; ages: 13-49 years; body weights: ...
Metabolism of Diazepam and Ethosuximide in rats with malaria and endotoxin-induced fever
(University of Nairobi., 1996-02)
We have investigated the effects of malaria infection with rodent parasite Plasmodium berghei and fever induced by Escherischia coli endotoxin on the metabolism of diazepam to temazepam by rat liver microsomes, and on the ...
Pharmacokinetics of oxamniquine in rabbit and rat
(University of Nairobi., 1996)
The pharmacokinetics of the schistosomicidal agent oxamniquine (6-hydroxmethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetra hydroquinoline) were studied in 8 (4 male, 4 female) New Zealand White rabbits and 5 female Wistar ...
Effect of route of administration on systematic availability of oxamniquine in the rabbit
(University of Nairobi., 1996-08)
Eight New Zealand white rabbits (4 females, 4 males) each received oxamniquine (15 mg kg(-1)) orally, rectally, intravenously and via the hepatic portal vein in a random cross-over study. Serial plasma samples were obtained ...
Oxamniquine inhibits metabolism of caffeine, hexobarbitone and antipyrine in vivo in mice
(University of Nairobi., 1996-08)
Inhibition of hepatic metabolism of caffeine (as assessed from expiration of (14)CO(2) resulting from N-demethylation of (14)C-labelled caffeine), hexobarbitone (as assessed from sleeping times) and antipyrine (as assessed ...