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A phase I double blind, placebo-controlled, randomized study of the safety and immunogenicity of electroporated HIV DNA with or without interleukin 12 in prime-boost combinations with an Ad35 hiv vaccine in healthy hiv-seronegative African Adults.
(University of Nairobi, 2015-08)
BACKGROUND:
Strategies to enhance the immunogenicity of DNA vaccines in humans include i) co-administration of molecular adjuvants, ii) intramuscular administration followed by in vivo electroporation (IM/EP) and/or ...
Nevirapine resistance in previously nevirapine-unexposed HIV-1 infected Kenyan infants initiating early antiretroviral therapy.
(University of Nairobi, 2015)
Nevirapine (NVP) resistance occurs frequently in infants following NVP use in prevention of mother-to-child transmission (PMTCT) regimens. However, among previously NVP-unexposed infants treated with NVP-ART, the development ...
Identification of preferential CD4+ T-cell targets for HIV infection in the cervix.
(University of Nairobi, 2015-05)
A better understanding of the cellular targets of HIV infection in the female genital tract may inform HIV prevention efforts. Proposed correlates of cellular susceptibility include the HIV co-receptor CCR5, peripheral ...
A 15-year study of the impact of community antiretroviral therapy coverage on HIV incidence in Kenyan female sex workers.
(University of Nairobi, 2015-07)
OBJECTIVE:
To test the hypothesis that increasing community antiretroviral therapy (ART) coverage would be associated with lower HIV incidence in female sex workers (FSWs) in Mombasa District, Kenya.
DESIGN:
Prospective ...
Cytotoxicity of 91 Kenyan indigenous medicinal plants towards human CCRF-CEM leukemia cells.
(University of Nairobi, 2015-12-22)
ETHNOPHARMACOLOGICAL RELEVANCE:
Plants from Kenyan flora are traditionally used against many ailments, including cancer and related diseases. Cancer is characterized as a condition with complex signs and symptoms. ...
Changes in the contribution of genital tract infections to HIV acquisition among Kenyan high-risk women from 1993 to 2012
(University of Nairobi, 2015)
Objective: The objective of this study was to understand temporal trends in the contribution of different genital tract infections to HIV incidence over 20 years of follow-up in a cohort of high-risk women.
Design: A ...
A scoring tool to identify East African HIV-1 serodiscordant partnerships with a high likelihood of pregnancy.
(University of Nairobi, 2015)
INTRODUCTION:
HIV-1 prevention programs targeting HIV-1 serodiscordant couples need to identify couples that are likely to become pregnant to facilitate discussions about methods to minimize HIV-1 risk during pregnancy ...
Potential effectiveness of community health strategy to promote exclusive breastfeeding in urban poor settings in Nairobi, Kenya: a quasi-experimental study.
(University of Nairobi, 2015)
Early nutrition is critical for later health and sustainable development. We determined potential effectiveness of the Kenyan Community Health Strategy in promoting exclusive breastfeeding (EBF) in urban poor settings in ...