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Cytotoxicity and Anti-hiv Activities of Extracts of the Twigs of Croton Dichogamus Pax
(University of Nairobi, 2022-02)
Background: Acquired immunodeficiency syndrome (AIDS) is a clinical syndrome resulting from infection with human immunodeficiency virus (HIV), which causes profound immunosuppression. Anti-HIV drugs that are currently ...
Constituents of Croton Megalocarpus With Potential Anti-hiv Activity
(University of Nairobi, 2022)
Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the ...
In Vitro Anti-hiv and Cytotoxic Effects of Pure Compounds Isolated From Croton Macrostachyus Hochst. Ex Delile
(University of Nairobi, 2022)
Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for cough, ...
Effects of cytochrome P450 2B6 and constitutive androstane receptor genetic variation on Efavirenz plasma concentrations among HIV patients in Kenya
(University of Nairobi, 2022-03)
The effects of genetic variation of cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) on efavirenz (EFV) plasma concentration was evaluated among 312 HIV patients in Nairobi Kenya. The EFV plasma ...
Anti-HIV crotocascarin ω from Kenyan Croton dichogamus
(University of Nairobi, 2022-10)
An anti-HIV methanol-soluble fraction of a 1:1 CH2Cl2:CH3OH extract of twigs of a Kenyan Croton dichogamus yielded seven compounds, the new crotocascarin ω (1), the known β-oplopanone (2), dihydroconiferyl acetate (3), ...