Search
Now showing items 1-9 of 9
Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions
(2014)
Research in the past two decades has generated unequivocal evidence that host genetic variations substantially account for the heterogeneous outcomes following human immunodeficiency virus type 1 (HIV-1) infection. In ...
The effects of aflatoxin exposure on Hepatitis B-vaccine induced immunity in Kenyan children.
(Elsevier, 2019-05)
BACKGROUND:
Globally, approximately three million children die each year from vaccine preventable infectious diseases mainly in developing countries. Despite the success of the expanded immunization program, not all infants ...
Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya.
(2014)
A qualitative assessment of Kenyan men who have sex with men taking daily and intermittent oral HIV pre-exposure prophylaxis (PrEP) found stigma, sex work, mobility, and alcohol impacted adherence. We analyzed quantitative ...
Pregnancy and HIV Disease progression in an early infection cohort from five African countries.
(Unuversity of Nairobi, 2017)
BACKGROUND:
Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women.
METHODS:
From 2006 to 2011, women less than age 40 ...
Clinical safety and immunogenicity of two hiv vaccines sev-g (np) and ad35-grin in HIV-uninfected, healthy adult volunteers
(University of Nairobi, 2014)
Development of vaccines that stimulate sustained humoral and/or cellular
immunity at mucosal HIV entry points is critical in the quest for an HIV vaccine. To achieve
this goal, we are investigating replication-competent ...
Assessment of anti-hiv-1 antibodies in oral and nasal compartments of volunteers from 3 different populations.
(University of Nairobi, 2016)
In this study, we assessed the feasibility of collecting standardized nasal and salivary samples at centers in Nairobi (Kenya), Kigali (Rwanda), and London (United Kingdom) using different collection devices and media ...
Broad HIV-1 inhibition in vitro by vaccine-elicited cd8(+) t cells in African adults.
(University of Nairobi, 2016)
We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally ...
The effects of exposures to mycotoxins on immunity in children: A systematic review.
(Elsevier, 2019-05)
The majority of childhood deaths occur in low-income countries, with vaccine-preventable infections contributing greatly. Of the many possible environmental factors that could hamper a child's immune response, mycotoxins ...
Mycoplasma genitalium Infection in Kenyan and US Women.
(Wolters Kluwer, 2018-08)
Little is known about the natural history of Mycoplasma genitalium (MG) infection in women. We retrospectively tested archived vaginal fluid samples to assess MG prevalence, incidence, persistence, recurrence and antimicrobial ...