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Systems biology-based approaches to understand HIV-exposed uninfected women.
(University of Nairobi, 2010-05)
Worldwide HIV infects women more frequently than men, and it is clear that not all exposed to HIV become infected. Several populations of HIV-exposed uninfected (EU) women have been identified, including discordant couples ...
HIV and Interferon Regulatory Factor 1: A Story of Manipulation and Control.
(University of Nairobi, 2013-11)
Members of the interferon regulatory factor (IRF) family control the expression of numerous proteins, many of which are central to regulating host immune responses. IRF1 is one of the central mediators of the innate and ...