Search
Now showing items 1-3 of 3
Epigenetic Control Of Irf1 Responses In HIV-exposed Seronegative Versus HIV-susceptible Individuals.
(University of Nairobi, 2011-03)
Not all individuals exposed to HIV become infected. Understanding why these HIV-exposed seronegative individuals remain uninfected will help inform the development of preventative measures against HIV infection. Interferon ...
Reducing IRF-1 to levels observed in HESN subjects limits HIV replication, but not the extent of Host immune activation.
(University of Nairobi, 2015-10)
Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1
(interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early ...
HIV and Interferon Regulatory Factor 1: A Story of Manipulation and Control.
(University of Nairobi, 2013-11)
Members of the interferon regulatory factor (IRF) family control the expression of numerous proteins, many of which are central to regulating host immune responses. IRF1 is one of the central mediators of the innate and ...