Now showing items 21-40 of 10062

    • Stakeholder-engaged research: strategies for the prevention and control of overweight and obesity in Kenya 

      Wanjau, Mary N; Kivuti-Bitok, Lucy W; Aminde, Leopold N; Veerman, J Lennert (University of Nairobi, 2021)
      Background: This study was done as part of a larger study that aims to identify the most impactful and cost-effective strategies for the prevention and control of overweight and obesity in Kenya. Our objective was to involve ...
    • Neurocognition in Kenyan youth at clinical high risk for psychosis 

      Mamah, Daniel; Mutiso, Victoria N; Ndetei, David M (University of Nairobi, 2021)
      Introduction: Cognitive deficits are typically seen in schizophrenia and in the prodrome, and are a major predictor of functional outcomes in patients. In Africa, few studies have investigated neurocognition in psychosis, ...
    • Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis 

      LaCourse, Sylvia M; Leon, Daniel; Panpradist, Nuttada; Richardson, Barbra A; Maleche-Obimbo, Elizabeth; Mecha, Jerphason; Matemo, Daniel; Escudero, Jaclyn N; Kinuthia, John; Lutz, Barry; John-Stewart, Grace (University of Nairobi, 2021)
      We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite ...
    • Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease 

      Kalaria, Rajesh N; Diego, Sepulveda-Falla (University of Nairobi, 2021)
      Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and neurodegeneration. However, current evidence ...
    • Cytotoxicity of isoflavones from Millettia dura 

      Buyinza, Daniel; Yang, Li Jun; Derese, Solomon; Ndakala, Albert; Coghi, Paolo; Heydenreich, Matthias; Wong, Vincent K W; Möller, Heiko M; Yenesew, Abiy (University of Nairobi, 2021-08)
      The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from ...
    • The 2021-2024 Work Plan of WPA Collaborating Centres 

      Andrea, Fiorillo; Bhui, Kamaldeep S; Stein, Dan J; Okasha, Tarek; Ndetei, David; Lam, Linda C W; Murthy, Pratima; Azeem, Muhammad W; Javed, Afzal (University of Nairobi, 2021-10)
    • The impact of COVID-19 on rheumatology practice across Africa. 

      Oyoo, Omondi; Akintayo, Richard O; Akpabio, Akpabio A; Kalla, Asgar A; Dey, Dzifa; Migowa, Angela N; Olaosebikan, Hakeem; Bahiri, Rachid; Miedany, Yasser El; Hadef, Djohra; Hamdi, Wafa; Slimani, Samy; Yerima, Abubakar; Taha, Yassmin; Adebajo, Adewale O; Adelowo, Olufemi O; Tikly, Mohammed; Ghozlani, Imad; Abdelghani, Kawther Ben; Fouad, Nermeen A; Mosad, Doaa; Mikkawy, Dalia El; Abu-Zaid, Mohamed H; Abdel-Magied, Rasha A (Oxford University Press, 2021)
      Objectives: To identify the changes in rheumatology service delivery across the five regions of Africa from the impact of the COVID-19 pandemic. Methods: The COVID-19 African Rheumatology Study Group created an online ...
    • A diverse collection of B cells responded to HIV infection in infant BG505. 

      Nduati, Ruth; Overbaugh, Julie; Doria-Rose, Nicole; Chohan, Vrasha; Itell, Hannah; Hennessy, Brianna; Cale, Evan M; Garrett, Meghan; Gobillot, Theodore; Doepker, Laura; Shipley, Mackenzie M; Simonich, Cassandra (University of Nairobi, 2021)
      Increasing evidence suggests infants develop unique neutralizing antibody (nAb) responses to HIV compared to adults. Here, we dissected the nAb response of an infant whose virus is in clinical trials as a vaccine immunogen, ...
    • The African Vaccine-Preventable Diseases Network: a vaccine advocacy initiative. 

      Were, Fredrick; Wiysonge, Charles S; Armah, George E; Madhi, Shabir A; Kitaka, Sabrina B; Akoua-Koffi, Chantal; Gresenguet, Gérard; Gatheru, Zipporah; Maranga, Patrick W; et al (University of Nairobi, 2011)
      Achieving high and equitable childhood immunisation coverage in Africa will not only protect children from disability and premature death, it will also boost productivity, reduce poverty and support the economic growth of ...
    • Feasibility of using an Early Warning Score for preterm or low birthweight infants in a low-resource setting. 

      Were, Fredrick; Qureshi, Zahida P; Gwako, George; Osoti, Alfred; Mitchell, Eleanor J; Daniels, Jane; Opira, Jacqueline; Bradshaw, Lucy; Oliver, Mary; Pallotti, Phoebe; Ojha, Shalini (University of Nairobi, 2020)
      Introduction Fifteen million babies are born prematurely, before 37 weeks gestational age, globally. More than 80% of these are in sub-Saharan Africa and Asia. 35% of all deaths in the first month of life are due to ...
    • WHO next-generation partograph: revolutionary steps towards individualised labour care. 

      Qureshi, Z; Hofmeyr, G J; Bernitz, S; Bonet, M; Bucagu, M; Dao, B; Downe, S; Galadanci, H; Homer, Cse; Hundley, V; Lavender, T; Levy, B; Lissauer, D; Lumbiganon, P; McConville, F E; Pattinson, R; Souza, J P; et al (University of Nairobi, 2021)
      No abstract available
    • Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease? 

      Nangole, Ferdinand W; Ouyang, Kelsey; Anzala, Omu; Ogengo, Julius; Agak, George W (University of Nairobi, 2021)
      Background Inflammation seems to play a major role in the pathophysiology of keloids. However, the role of cytokines in keloid pathophysiology has not been fully evaluated with only a few cytokines studied. We undertook ...
    • Cancer and COVID-19 Experiences at African Cancer Centers: The Silver Lining. 

      Mwango, Gladys; Ochieng, Primus; Grossheim, Linda; Ruff, Paul; Ngoma, Twalib; Vanderpuye, Verna; Palmer, Dennis; Kouya, Francine; et al (University of Nairobi, 2021)
      PURPOSE The COVID-19 pandemic significantly disrupted cancer care in Africa, further exposing major health disparities. This paper compares and contrasts the experiences of 15 clinicians in six different African cancer ...
    • sssHigh seroprevalence of SARS-CoV-2 but low infection fatality ratio eight months after introduction in Nairobi, Kenya. 

      Masika, Moses; Ngere, Isaac; Dawa, Jeanette; Hunsperger, Elizabeth; Otieno, Nancy; Amoth, Patrick; Makayotto, Lyndah; Nasimiyu, Carolyne; Gunn, Bronwyn M; et al (Elsevier Ltd, 2021)
      Background: The lower-than-expected COVID-19 morbidity and mortality in Africa has been attributed to multiple factors, including weak surveillance. We estimated the burden of SARS-CoV-2 infections eight months into the ...
    • What Is the Appropriate Age Range of Individuals to Be Included in a Survey to Estimate the Prevalence of Trachomatous Trichiasis? 

      Karimurio, Jefitha; Rono, Hillary; Mesurier, Richard L; Mutuku, Mwanthi; Keeffe, Jill (University of Nairobi, 2011)
      Introduction A survey to determine the prevalence of trachomatous trichiasis (TT) requires a large sample size and the recommended participant age is ≥15 years. This study sought to establish the appropriate age range of ...
    • Discolouration of teeth: an overview of the diagnosis and management 

      Wakiaga, J; Kisumbi, B; Chindia, M L (University of Nairobi, 1995)
      The dentist is faced with a daunting task in application of clinical skills to achieve maximum cosmetic results when it comes to the management of discoloured and/or hypoplastic dentition. In this paper, an overview is ...
    • The Role of Targeted Nutrition Education of Preschoolers and Caregivers on Sustained Consumption of Biofortified Orange-Fleshed Sweetpotato in Kenya 

      Ojwang, Sylvester O; Otieno, David J; Okello, Julius J; Nyikal, Rose A; Muoki, Penina (University of Nairobi, 2021-07)
      Background: Persistent prevalence of high malnutrition in poor households in developing countries calls for enhancement of cost-effective nutrition interventions among the vulnerable groups. One responsive way is to promote ...
    • Effect of Shamiri Layperson-Provided Intervention vs Study Skills Control Intervention for Depression and Anxiety Symptoms in Adolescents in Kenya: A Randomized Clinical Trial 

      Osborn, Tom L; Venturo-Conerly, Katherine E; Arango, Susana; Roe, Elizabeth; Rodriguez, Micaela; Alemu, Rediet G; Gan, Jenny; Wasil, Akash R; Otieno, Benny H; Rusch, Thomas; Ndetei, David M; Wasanga, Christine; Jessica, L Schleider; Weisz, John R (University of Nairobi, 2021-08)
      Importance: Low-cost interventions for adolescent depression and anxiety are needed in low-resource countries such as those in Sub-Saharan Africa. Objective: To assess whether Shamiri, a 4-week layperson-delivered group ...
    • Applying human-centered design to maximize acceptability, feasibility, and usability of mobile technology supervision in Kenya: a mixed methods pilot study protocol 

      Triplett, Noah S; Munson, Sean; Mbwayo, Anne; Mutavi, Teresia; Weiner, Bryan J; Collins, Pamela; Cyrilla, Amanya; Dorsey, Shannon (2021-01)
      Background: Although research continues to support task-shifting as an effective model of delivering evidence-based practices (EBPs), little scholarship has focused how to scale up and sustain task-shifting in low- and ...
    • Impact of COVID-19 on Cancer Care Delivery in Africa: A Cross-Sectional Survey of Oncology Providers in Africa 

      Martei, Yehoda M; Rick, Tara J; Temidayo, Fadelu; Mohammed, S Ezzi; Nazik, Hammad; Nasreen, S Quadri; Belmira, Rodrigues; Hannah, Simonds; Surbhi, Grove; Incrocci, Luca; Vanderpuye, Verna (University of Nairobi, 2021-03)
      Purpose: The COVID-19 pandemic has disrupted cancer care globally. There are limited data of its impact in Africa. This study aims to characterize COVID-19 response strategies and impact of COVID-19 on cancer care and ...