dc.contributor.author | Kiruku, M.G | |
dc.date.accessioned | 2015-02-20T06:47:25Z | |
dc.date.available | 2015-02-20T06:47:25Z | |
dc.date.issued | 1987 | |
dc.identifier.citation | A project submitted in partial fulfilment of the requirement of the award of the degree of bachelor of pharmacy. | en_US |
dc.identifier.uri | http://hdl.handle.net/11295/80605 | |
dc.description.abstract | The project was intended to compare relative bioavailabilities
f 4 brands of acetylsalicylic acid tablets as well as to establish
ether a correlation exists between in-vitro dissolution rate and
inary excretion analysiso
The official chemical analysis of the tablets showed that
I the tablets contained amounts of acetylsalicylic acid within
le required official limitso
I
The B.P. method of obtaining disintegration times of the
lblets was adopted and the brands had a rank order of: C
~astest rate), D,B,Ao
The dissolution profiles of the 4 brands was obtained
employing the rotating basket method (U.S.P). The rank order
sed on the rate of drug release ran as: B{most superior), D,C,
The in-vivo(urinary excretion) analysis was conducted
urine sampleso These samples were periodically obtained from
catheterized. male rabit. The rank order of bioavailability was
tained after~y)compu ing th7 area under the curve in the plot
cumulative amount of drug excreted versus timeo The order
s: B(highest% bioavailability),D,C,A.
The in-vitro dissolution rates were found to correlate
th the in-vivo results. No correlation could be established
tween in-vitro dissolution rates and disintegration times. | en_US |
dc.title | A comparative study of bioavailabity of brands of acetylsalicylic acid tablets from different manufacturers | en_US |
dc.type | Thesis | en_US |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
dc.type.material | en_US | en_US |