dc.contributor.author | Land, Allison M | |
dc.contributor.author | Luo, Ma | |
dc.contributor.author | Pilon, Richard | |
dc.contributor.author | Sandstrom, Paul | |
dc.contributor.author | Embree, Joanne | |
dc.contributor.author | Wachihi, Charles | |
dc.contributor.author | Kimani, Joshua | |
dc.contributor.author | Plummer, Francis A | |
dc.contributor.author | Ball, T Blake | |
dc.date.accessioned | 2015-04-02T12:19:45Z | |
dc.date.available | 2015-04-02T12:19:45Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Allison M. Land, Ma Luo, Richard Pilon, Paul Sandstrom, Joanne Embree, Charles Wachihi, Joshua Kimani, Francis A. Plummer, and T. Blake Ball. AIDS Research and Human Retroviruses. November 2008, 24(11): 1455-1460. | en_US |
dc.identifier.uri | http://online.liebertpub.com/doi/abs/10.1089/aid.2008.0179 | |
dc.identifier.uri | http://hdl.handle.net/11295/81893 | |
dc.description.abstract | HIV-1, a highly diverse infectious agent, shows the greatest sequence diversity in highly exposed individuals, including greater levels of recombination. HIV-1 diversity in Nairobi, Kenya was examined in 240 individuals, including both those with high and low exposure to HIV. Sequence analysis of a 590 nucleotide proviral region encompassing vpu and part of env revealed that most viruses were clade A1 (70%), while both clade D (9%) and clade C (6%) virus were also observed, as was recombinant virus (15%). Participation in sex work was significantly associated with clade: these subjects had a lower likelihood of infection with clade C virus and a higher likelihood of infection with a recombinant isolate (p = 0.038). Interestingly, most of the recombinants formed distinct groups based on shared recombination breakpoints between common clades (n = 33/37). This study shows the value of continued HIV sequence analysis to examine and monitor viral genetic variability. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | High Prevalence of Genetically Similar HIV-1 Recombinants among Infected Sex Workers in Nairobi, Kenya | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |