dc.contributor.author | Lel, Rency | |
dc.contributor.author | Ngaira, Jane | |
dc.contributor.author | Lihana, Raphael | |
dc.contributor.author | Khamadi, Samoel. | |
dc.date.accessioned | 2015-04-02T12:54:11Z | |
dc.date.available | 2015-04-02T12:54:11Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Lel Rency, Ngaira Jane, Lihana Raphael, and Khamadi Samoel. AIDS Research and Human Retroviruses. December 2014, 30(12): 1236-1238. | en_US |
dc.identifier.uri | http://hdl.handle.net/11295/81895 | |
dc.description.abstract | To determine HIV-1 subtypes and transmitted HIV-1 drug-resistant mutations among HIV-1-positive children born to HIV-positive mothers in Busia County, blood samples were collected from 53 children aged between 6 weeks and 5 years in 2011. Their mothers were HIV-1 positive and on antiretroviral therapy at the time the children were born. The samples were analyzed for HIV-1 drug resistance and subtypes through sequencing of portions of the HIV-1 pol gene. The generated sequences were analyzed for subtype diversity using the REGA and BLAST subtyping tools. HIV-1 drug resistance was determined using the Stanford University HIV database. Of the 53 samples that were successfully amplified and sequenced, 69.8% (37/53) were determined to be HIV-1 subtype A, 22.6% (12/53) were subtype D, 5.6% (3/53) were subtype C, and 1.8% (1/53) were subtype A1C. The prevalence of HIV-1 drug resistance mutations of any kind was 22.6% (12/53). | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | HIV-1 Drug Resistance Mutations Among Infants Born to HIV-Positive Mothers in Busia, Kenya | en_US |
dc.type.material | en | en_US |