dc.identifier.citation | Otieno, SB.,Were, F.,Kabiru, EW (2014). The effects of yeast selenium on cd4 t cell count of non -institutionalized HIV type 1 positive orphan children at Orongo widows and orphans in Kisumu Kenya. International journal of humanities and social science, 4(3); pp. 233-241 | en_US |
dc.description.abstract | Background:
Multi drug resistance HIV has emerged rendering the current conventional treatment of HIV
ineffective. There is a need for new treatment regime which is cheap, effective and not prone to res
istance
development by HIV
.
Methods:
In randomized cli
nical study of 68 HIV positive children 3
–
15 years to asses the efficacy of yeast
selenium in HIV/AIDS patients, 50μ yeast selenium was administered to 34 children while in matched c
ontrol of
34 were put on placebo. Blood
samples of
the both groups whic
h were taken every 3 months intervals up to 6
months, were analyzed by ELI
S
A for CD4T cells, the data was analyzed by SPSS version 16.
Results:
No significant difference in age { χ
2
(1, 62) =0.03, p =0.853}, cause of morbidity between test and
controls {χ
2
( 1, 65) = 5.87, p= 0.015} and on condition of foster parents {χ
2
( 1,63) = 5.57, p= 0.0172} was
observered.
Children on selenium showed progressive improvement of WAZ and significant difference at six
months{F (5,12) = =5.758, P=0.006}, and weight gain
of up to2.5kilograms in six months, and significant CD4 T
cell count increase t =
-
2.943,p< 0.05 compared to matched controls t =
-
1.258 p> 0.05. CD4 T cell count
increased among all age groups on test 3
-
5years (+ 267.1),5
-
8 years( +200.3) 9
-
15 years (
+71.2) cells/mm
3
and in matched controls a decrease 3
-
5 years(
-
71),5
-
8 years (
-
125) and 9
-
13years(
-
10.1)cells/mm
3
. No
significant difference
in CD4 T cell count
between girls
{F (2, 32) = 1.531 p= 0.232} and between boys {F (2, 49)
= 1.040, p= 0.361} on
test and between boys and girls {F (5, 81) = 1.379, p= 0.241} on
control
was observed.
Conclusion:
From this study it can be concluded that administration of yeast Selenium led to slowing the
progress of HIV 1 in children from WHO clinical stage I by i
mproving CD4 T cell count and hence the immunity | en_US |