| dc.contributor.author | Hardie, Rae-Anne | |
| dc.contributor.author | Knight, Erin | |
| dc.contributor.author | Bruneau, Brigitte | |
| dc.contributor.author | Semeniuk, Christina | |
| dc.contributor.author | Gill, Kulvinder | |
| dc.contributor.author | Nagelkerke, Nico | |
| dc.contributor.author | Kimani, Joshua | |
| dc.contributor.author | Wachihi, Charles | |
| dc.contributor.author | Ngugi, Elizabeth | |
| dc.contributor.author | Luo, Ma | |
| dc.contributor.author | Plummer, Francis A | |
| dc.date.accessioned | 2015-05-19T09:49:11Z | |
| dc.date.available | 2015-05-19T09:49:11Z | |
| dc.date.issued | 2008-10 | |
| dc.identifier.citation | AIDS. 2008 Oct 1; 22(15): 2038–2042. | en_US |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683274/ | |
| dc.identifier.uri | http://hdl.handle.net/11295/83182 | |
| dc.description.abstract | HLA-DP antigens present peptides to CD4+ T cells and play an important role in parasitic infections and autoimmune diseases, yet their influence on HIV-1 susceptibility has not been well studied. Here, we report several HLA-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency=60.4%) was associated with HIV-resistance (P=0.033, odds ratio=1.585, 95% confidence interval=1.036-2.425) and slower seroconversion (P=0.001, log rank=0.595, 95% confidence interval=0.433-0.817). The discovery of common HLA-DP antigens contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic HLA antigens. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Univerisyt of Nairobi | en_US |
| dc.subject | HIV-1, Sex Workers, HLA-DPA1, HLA-DPB1, Disease Association, Disease Resistance, DNA Sequence Analysis | en_US |
| dc.title | A common HLA-DP genotype is associated with resistance to hiv-1 infection in Kenyan sex workers | en_US |
| dc.type | Article | en_US |
| dc.type.material | en | en_US |
