Frequency of false positive rapid HIV serologic tests in African men and women receiving prep for HIV prevention: implications for programmatic roll-out of biomedical interventions
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Date
2015-04-17Author
Ndase, Patrick
Celum, Connie
Kidoguchi, Lara
Ronald, Allan
Fife, Kenneth H
Bukusi, Elizabeth
Donnell, Deborah
Baeten, Jared M.
Language
enMetadata
Show full item recordAbstract
Background
Rapid HIV assays are the mainstay of HIV testing globally. Delivery of effective biomedical
HIV prevention strategies such as antiretroviral pre-exposure prophylaxis (PrEP) requires
periodic HIV testing. Because rapid tests have high (
>
95%) but imperfect specificity, they
are expected to generate some false positive results.
Methods
We assessed the frequency of true and false positive rapid results in the Partners PrEP
Study, a randomized, placebo-controlled trial of PrEP. HIV testing was performed monthly
using 2 rapid tests done in parallel with HIV enzyme immunoassay (EIA) confirmation fol-
lowing all positive rapid tests.
Results
A total of 99,009 monthly HIV tests were performed; 98,743 (99.7%) were dual-rapid HIV
negative. Of the 266 visits with
1 positive rapid result, 99 (37.2%) had confirmatory posi-
tive EIA results (true positives), 155 (58.3%) had negative EIA results (false positives), and
Citation
PLoS One. 2015; 10(4): e0123005Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]