Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.
dc.contributor.author | Mackelprang, RD | |
dc.contributor.author | Scoville, CW | |
dc.contributor.author | Cohen, CR | |
dc.contributor.author | Ondondo, RO | |
dc.contributor.author | Bigham, AW | |
dc.contributor.author | Celum, C | |
dc.contributor.author | Campbell, MS | |
dc.contributor.author | Essex, M | |
dc.contributor.author | Wald, A | |
dc.contributor.author | Kiarie, J | |
dc.contributor.author | Ronald, A | |
dc.contributor.author | Gray, G | |
dc.contributor.author | Lingappa, JR | |
dc.date.accessioned | 2015-06-23T07:58:03Z | |
dc.date.available | 2015-06-23T07:58:03Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/25928881 | |
dc.identifier.uri | http://hdl.handle.net/11295/85477 | |
dc.description.abstract | Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV, whereas TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women.Genes and Immunity advance online publication, 30 April 2015; doi:10.1038/gene.2015.13. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women. | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |
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