Pharmacological Activities of Vernonia glabra
Date
1996Author
Achola, K J
Mwangi, J W
Munenge, R W
Mwaura, A M
Language
enMetadata
Show full item recordAbstract
A 70% methanol aerial part extract of Vernonia glabra caused a fall in blood pressure in anaesthetised rats. After the 50 µg dose, systolic, diastolic, and mean blood pressures decreased by 56%, 66%, and 61% respectively below the baseline levels. The adrenaline-like activity of the extract was not antagonised by L(-) propranolol on isolated rabbit heart. The extract caused contraction on the isolated rabbit ileum and was abolished with atropine, suggesting the presence of a compound with acetylcholine-like activity. The extract on isolated guinea pig ileum caused contraction which was dose related.
URI
http://informahealthcare.com/doi/abs/10.1076/phbi.34.2.141.13190http://hdl.handle.net/11295/88824
Citation
Pharmaceutical Biology, 1996, Vol. 34, No. 2 : Pages 141-144Collections
- Faculty of Health Sciences (FHS) [10387]