Host Genetic and Viral Determinants of HIV-1 RNA Set Point among HIV-1 Seroconverters from Sub-Saharan Africa
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Date
2015-09-03Author
Mackelprang, Romel D.
Carrington, Mary
Thomas, Katherine K
Hughes, James P.
Jared, M. Baeten
Wald, Anna
Farquha, Carey
Fife, Kenneth
[et al.]
Language
enMetadata
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ABSTRACT
We quantified the collective impact of source partner HIV-1 RNA levels, human leukocyte antigen (HLA) alleles, and innate re-
sponses through Toll-like receptor (TLR) alleles on the HIV-1 set point. Data came from HIV-1 seroconverters in African HIV-1
serodiscordant couple cohorts. Linear regression was used to determine associations with set point and
R
2
to estimate variation
explained by covariates. The strongest predictors of set point were HLA alleles (B*53:01, B*14:01, and B*27:03) and plasma
HIV-1 levels of the transmitting partner, which explained 13% and 10% of variation in set point, respectively. HLA-A concor-
dance between partners and TLR polymorphisms (
TLR2
rs3804100 and
TLR7
rs179012) also were associated with set point, ex-
plaining 6% and 5% of the variation, respectively. Overall, these factors and genital factors of the transmitter (i.e., male circum-
cision, bacterial vaginosis, and use of acyclovir) explained 46% of variation in set point. We found that both innate and adaptive
immune responses, together with plasma HIV-1 levels of the transmitting partner, explain almost half of the variation in viral
load set point
URI
http://jvi.asm.org/content/89/4/2104.full.pdf+html?sid=4e72f5dc-8f4f-4243-854c-2aa037ce1e4dhttp://hdl.handle.net/11295/90384
Citation
Mackelprang, R. D., Carrington, M., Thomas, K. K., Hughes, J. P., Baeten, J. M., Wald, A., ... & Lingappa, J. R. (2015). Host Genetic and Viral Determinants of HIV-1 RNA Set Point among HIV-1 Seroconverters from Sub-Saharan Africa. Journal of virology, 89(4), 2104-2111.Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]