| dc.contributor.author | Maina, Godfrey | |
| dc.date.accessioned | 2015-09-24T06:38:22Z | |
| dc.date.available | 2015-09-24T06:38:22Z | |
| dc.date.issued | 1974 | |
| dc.identifier.citation | Biochimica et Biophysica Acta (BBA) - Bioenergetics Volume 333, Issue 3, 26 March 1974, Pages 481-486 | en_US |
| dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/0005272874901327 | |
| dc.identifier.uri | http://hdl.handle.net/11295/91402 | |
| dc.description.abstract | 1. Reserpine, like the uncoupling agent, 2,4-dinitrophenol prevents oxidative phosphorylation but stimulates the rate at which oxygen is reduced.
2. Both reserpine and 2,4-dinitrophenol fail to stimulate oxygen uptake by isolated mitochondria in the presence of arginine.
3. Both 2,4-dinitrophenol and reserpine induce proton permeability in the mitochondrial membrane so that H+ is absorbed from the suspending medium.
4. When the reaction system contains reserpine, accumulation of Ca2+ by mitochondria is inhibited.
5. Reserpine decreases both ADP:O and P:O ratios which strongly suggest that reserpine is an uncoupling agent. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.title | Reserpine as an uncoupling agent | en_US |
| dc.type | Article | en_US |
| dc.type.material | en | en_US |
