Dysfibrinogenaemia and Primary Hepato-Cellular Carcinoma

dc.contributor.author	Barr, RD
dc.contributor.author	Ouna, N
dc.contributor.author	Simpson, JG
dc.contributor.author	Bagshawe, AF
dc.date.accessioned	2015-10-01T06:51:02Z
dc.date.available	2015-10-01T06:51:02Z
dc.date.issued	1976
dc.identifier.citation	QJM: An International Journal of MedicineVolume 45, Issue 4Pp. 647 - 659	en_US
dc.identifier.uri	http://qjmed.oxfordjournals.org/content/45/4/647
dc.identifier.uri	http://hdl.handle.net/11295/91669
dc.description.abstract	The mechanisms of blood coagulation and fibrinolysis have been evaluated in 28 black adult Africans with primary hepato-cellular carcinoma (HCC). A characteristic pattern of abnormalities has been defined. Dysnbrinogenaemia appears to be a useful biological marker for the disease. The reptilase test (RT) is a simple, reliable and sensitive means of detection of this metabolic abnormality. It is suggested that the RT should be used to screen populations at high risk of developing HCC, such as cirrhotics, in conjunction with α fetoprotein determinations, which, alone, are inadequate for the purpose. The haemostatic defect may have relevance to the patho-genesis of HCC, and further suggests a potentially useful, additional, therapeutic modality.	en_US
dc.language.iso	en	en_US
dc.publisher	University of Nairobi	en_US
dc.title	Dysfibrinogenaemia and Primary Hepato-Cellular Carcinoma	en_US
dc.type	Article	en_US
dc.type.material	en	en_US