dc.contributor.author | Ogeng’o, Julius A | |
dc.contributor.author | Maseghe, Phillip | |
dc.contributor.author | Ongeti, Kevin | |
dc.contributor.author | Obimbo, Moses | |
dc.contributor.author | Olabu, Beda | |
dc.date.accessioned | 2015-11-27T07:20:04Z | |
dc.date.available | 2015-11-27T07:20:04Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Ogeng’o, J. A., Maseghe, P., Ongeti, K., Obimbo, M., & Olabu, B. Tunica Adventitia of the Aorta is an Active Vascular Compartment. Anatomy J ournal of Africa. 2015. Vol 4 (2 ) : 617 - 62 3 . | en_US |
dc.identifier.uri | http://www.anatomyafrica.org/Vol4issue2/jao.pdf | |
dc.identifier.uri | http://hdl.handle.net/11295/92677 | |
dc.description.abstract | The tunica adventitia
has previously been regarded as a passive connective tissue covering that offers
only nutritive and physical support to the arterial wall
. Recently
, however,
emphasis has been given to
its
role in atherosclero
sis. Although the normal structure may bear the anatomical basis of these
functions, microscopic anatomy of the tunica adventitia
in
normal
arteries
is seldom reported. These
data are important in understanding disease process and potential areas of inte
rvention. The goat is a
suitable model for studying cardiovascular disease and the aorta is frequently afflicted by
atherosclerosis. This study
,
therefore, aimed at describing the structure of tunica adventitia of normal
aorta in goat.
Materials for the
study were obtained from abdominal aorta of 6 healthy
young adult
male goats (capra hircus)
age range 12
–
24 months. Fresh specimens from euthanized animals
were
fixed in
3% phosphate buffered
glutaraldehyde, post
fixed in
1% phosphate buffered
osmium te
troxide
then embedded in
durcupan
. Ultrathin sections were stained with uranyl acetate count
erstai
ned with
lead citrate and examined with electron microscope. Some
specimens were processed routinely
for
paraffin embedding and sectioning. They were stain
ed with Mason’s
Trichrome and Weigert
elastic/V
an Gieson stains.
The tunica adventitia was fibroelastic with numerous capillaries, arter
ioles
and multiple cell types.
The cells were active fibroblasts, phagocytic, perivascul
a
r and endothelial cells
embedd
e
d in the fibrous stroma.
These findings suggest that the tunica adventitia
of the goat aorta
is
a metabolically active vascular compartment. These features namely microvasculature and multiple cell
population
s probably enable it to maintain
structural an
d functional
integrity and
appropriately
respond
to vascular injury | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.subject | Tunica Adventitia, cells, Capillaries, Arterioles, Atherosclerosis | en_US |
dc.title | Tunica Adventitia of the Aorta is an Active Vascular Compartment. | en_US |
dc.type | Article | en_US |