Pharmacological Screening For Anti-inflammatory Activity In A Novel Series Of Compounds Bridging Steroidal And Non-steroidal Drugs.
View/ Open
Date
1984Author
Kinyanjui, James M
Type
ThesisLanguage
enMetadata
Show full item recordAbstract
1. A Novel Series of Compounds bridging steroidal and Non-steroidal agents have been synthesized in the Department of Pharmacy, University of Nairobi and were screened for anti-inflammatory activity.
2. A standard Model, Inhibition of Carrageenan induced Rat Paw oedema was used with slight modifications.
3. Renal changes were assessed in Rats and were found to be comparable with agents used Clinically.
4. It was concluded that the compound FK13 AC-CL at low doses was more potent than Indomethacin. It is also possible that at Low doses the compounds have a similar mechanism of action to Nonsteroidal
Anti-inflammatory agents and at higher doses similar to steroidal anti-inflammatory Agents.
5. The usefulness of other pharmacological models like the Delayed Manifestation of Ultra Violet (UV) induced Erythema in Guinea-Pig in the assesment of mode of Action of these compounds, which is postulated to be via inhibition of PG Synthesis at two levels, is discussed.
Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
The following license files are associated with this item: