The Pharmacokinetic Of Sulphadiazine Sodium Injection In A Rabbit (Intraveneously) By Single Dose

Abstract

This investigation determined the pharmacokinetic parameters of sulphadiasine following rapid intraveneous injection into rabbits. It also determined the type of compartment mode and the effect of administering different doses in increasing order on the pharmacokinetic parameters. In both cases blood samples were collected at regular intervals after an i/v hours to administration and sulphadiasine analysed in each sample by calorimetric method. It was done for each dose. Plot of log concentration of plasma sulphadiasine against time was done to enable determination of pharmacokinetic parameters eg half-life, elimination constant total clerance and apparent volume of distribution and area under the curve. This was also done for each dose. To establish the effect of increasing dose on pharmacokinetic parameters a plot of area under the curve against dose was done. Results of these investigation showed that the plasma profile of sulphadiasine in rabbit was best described by one compartment model. It was also established that there was a linear mvlationship between the dose and the area under the curve suggesting that increase in dose did not have significant effect on the half-life and elimination rate constant.