Pterocarpans and isoflavones from the root bark of millettia micans and of millettia dura
Date
2016Author
Makungu, Marco
Tsegaye, Deyou
Amra, Gruhonjic
Holleran, John P.
Sandra, Duffy
Matthias, Heydenreich
Fitzpatrick, Paul A.
Göran, Landberg
Andreas, Koch
Solomon, Derese1, J P
Avery, Vicky M.
Máté, Erdélyi
Abiy, Yenesew
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
From the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan,
(6aR,11aR)-7,8,9-trimethoxy-3-hydroxypterocarpan (1), named micanspterocarpan, was isolated. Similar
investigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further new pterocarpan,
3-O-prenylmaackiain (2) along with six known isoflavones (3-8) and a chalcone (9). All purified
compounds were identified by NMR and MS, and the absolute configuration of 1 was established by quantum
chemical CD calculation. The isolated constituents, calopogonium isoflavone B (3) and isoerythrin A-4'(3-methylbut-2-enyl)
ether (4) showed marginal activities against the 3D7 and the Dd2 strains of Plasmodium
falciparum (70-90% inhibition at 40 M). Maximaisoflavone B (5) and 7,2'-dimethoxy-4',5'methylenedioxyisoflavone
(7) were weakly cytotoxic (IC50 153.5 and 174.1 M, respectively) against the
MDB-MB-231 human breast cancer cell line. None of the tested compounds showed toxicity against the
HEK-293 human embryonic kidney cell line at 40 M.
Citation
Yenesew A. "Two pterocarpans from Millettia dura and Millettia micans." Advances in Drug Discovery and Development. 2016;1(1):1-8.Publisher
University of Nairobi
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Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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