Pterocarpans and isoflavones from the root bark of millettia micans and of millettia dura
dc.contributor.author | Makungu, Marco | |
dc.contributor.author | Tsegaye, Deyou | |
dc.contributor.author | Amra, Gruhonjic | |
dc.contributor.author | Holleran, John P. | |
dc.contributor.author | Sandra, Duffy | |
dc.contributor.author | Matthias, Heydenreich | |
dc.contributor.author | Fitzpatrick, Paul A. | |
dc.contributor.author | Göran, Landberg | |
dc.contributor.author | Andreas, Koch | |
dc.contributor.author | Solomon, Derese1, J P | |
dc.contributor.author | Avery, Vicky M. | |
dc.contributor.author | Máté, Erdélyi | |
dc.contributor.author | Abiy, Yenesew | |
dc.date.accessioned | 2016-12-09T10:08:10Z | |
dc.date.available | 2016-12-09T10:08:10Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Yenesew A. "Two pterocarpans from Millettia dura and Millettia micans." Advances in Drug Discovery and Development. 2016;1(1):1-8. | en_US |
dc.identifier.uri | http://hdl.handle.net/11295/97957 | |
dc.description.abstract | From the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan, (6aR,11aR)-7,8,9-trimethoxy-3-hydroxypterocarpan (1), named micanspterocarpan, was isolated. Similar investigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further new pterocarpan, 3-O-prenylmaackiain (2) along with six known isoflavones (3-8) and a chalcone (9). All purified compounds were identified by NMR and MS, and the absolute configuration of 1 was established by quantum chemical CD calculation. The isolated constituents, calopogonium isoflavone B (3) and isoerythrin A-4'(3-methylbut-2-enyl) ether (4) showed marginal activities against the 3D7 and the Dd2 strains of Plasmodium falciparum (70-90% inhibition at 40 M). Maximaisoflavone B (5) and 7,2'-dimethoxy-4',5'methylenedioxyisoflavone (7) were weakly cytotoxic (IC50 153.5 and 174.1 M, respectively) against the MDB-MB-231 human breast cancer cell line. None of the tested compounds showed toxicity against the HEK-293 human embryonic kidney cell line at 40 M. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Millettia micans; Millettia dura; Micanspterocarpan; 3-O-Prenylmaackiain; Pterocarpan; Isoflavone; Cytotoxicity; Plasmodium falciparum. | en_US |
dc.title | Pterocarpans and isoflavones from the root bark of millettia micans and of millettia dura | en_US |
dc.type | Article | en_US |
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