Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response
Date
2009Author
Bosch, Katherine A.
Rainwater, Stephanie
Jaoko Walter G.
Overbaugh, Julie
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The origin of broadly neutralizing HIV-specific antibodies and their relation to HIV evolution are not well
defined. Here we examined virus evolution and neutralizing antibody escape in a subtype A infected
individual with a broad, cross subtype, antibody response. The majority of envelope variants isolated over
the first ∼5 years after infection were poorly neutralized by contemporaneous plasma that neutralized
variants from earlier in infection, consistent with a dynamic process of escape. The majority of variants could
be neutralized by later plasma, suggesting these evolving variants may have contributed to the elicitation of
new antibody responses. However, some variants from later in infection were recognized by plasma from
earlier in infection, including one notably neutralization-sensitive variant that was sensitive due to a proline
at position 199 in V2. These studies suggest a complex pattern of virus evolution in this individual with a
broad NAb response, including persistence of neutralization-sensitive viruses
URI
http://www.ncbi.nlm.nih.gov/pubmed/20034648http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9894
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823950/
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- Faculty of Health Sciences (FHS) [10387]